L.A. KOZLOV, A.M. KHANOVA, R.R. TALIPOVA, A.M. KHASANOVA, A.R. GALYAVEEVA

Kazan State Medical University, 49 Butlerov Str., Kazan, Russian Federation, 420012

Kozlov L.A. ― D. Sc. (medicine), Professor of the Department of Obsterics and Gynecology named after Prof. V.S. Gruzdev, tel. (843) 234-59-55, e-mail: klev1930@yandex.ru

Khanova A.M., Talipova R.R., Khasanova A.M., Galyaveeva A.R. ― 5-year students of Therapy Faculty

The article shows formation and development of the Prof. V.S. Gruzdev and his disciples’ research of uterine contraction. Their research was devoted to introducing medications regulating birth process in case of weak contractions and birth initiation. Initially, V.S. Gruzdev independently tested maize smut (ergot) with good results. Then, as pituitrin was discovered, V.S. Gruzdev instructed M.S. Malinovskiy to test the hormone in clinic conditions with unbiased registration of its effect onto uterus. Based on measurements of intra-uterine pressure during delivery, M.S. Malinovskiy established that the drug was to be introduced in delivery practice. Thus, M.S. Malinovskiy set a wide road to introduction of pituitrin in Russia. As oxytocin (equivalent of pituitrin lacking its negative properties) was developed, Z.N. Yakubova and K.V. Voronin tested it successfully during delivery and advised its introduction into practice, while N.V. Yakovlev demonstrated decreased surgical hemorrhage during abdominohysterotomy when oxytocin was applied immediately after extraction of infant from uterus. Further 100 years long development of the theory of uterine contractions and its regulation by the representatives of the second generation of Gruzdev’s school is shown.

Key words: pregnancy, delivery, contractions, asthenia, pituitrin, oxytocin.

(For citation: Kozlov L.A., Khanova A.M., Talipova R.R., Khasanova A.M., Galyaveeva A.R. Works by Professor V.S. Gruzdev and his disciples on uterine contractions (for the 150^th anniversary of Professor V.S. Gruzdev) . Practical Medicine. 2018) 

REFERENCES

1. Manenkov P.V. V.S. Gruzdev. Moscow, 1952. P. 136.
2. Gruzdev V.S. Corn smut (Ustilago maydis) as a means of enhancing the uterine contraction of the uterus. Vrach, 1894, no. 19 (in Russ.).
3. Zharkin A.F., Saakova V.G. Korifey akusherskoy nauki [Coryphium obstetric science]. Volgograd, 2002. P. 15.
4. Yakubova Z.N. Vnutrivennoe primenenie pituitrina s glyukozoy vo vtorom i tretʹem periodakh rodov. Sbornik nauchnykh rabot KGMI [ Intravenous use of pituitrin with glucose in the second and third periods of labor. Collection of scientific works KGMI]. Kazan, 1957. Pp. 180-185.
5. Yakubova Z.N. K voprosu o profilaktiki atonicheskikh krovotecheniy. Sbornik nauchnykh rabot KGMI [On the issue of prevention of atonic bleeding. Collection of scientific works KGMI]. Kazan, 1957. Pp. 186-190.
6. Voronin K.V. Sovremennye printsipy vedeniya rodov i poslerodovogo perioda pri tyazhelom pozdnem toksikoze beremennykh: avtoref. dis. … dok. med. nauk [Modern principles of labor and the postpartum period in severe late toxicosis of pregnant women. Synopsis of dis. Dr med. sciences]. Moscow, 1977.
7. Eremkina V.I., Golovanova N.V. Rodovozbuzhdenie vnutrivennym kapelʹnym vvedeniem prostenona i oksitotsina [Labor induction by intravenous drip of prostenone and oxytocin]. Tez. dokl. 2-go obʺedinennogo sʺezda akusherov-ginekologov i detskikh vrachey Chuvashskoy ASSR. Cheboksary, 1987.
8. Eremkina V.I., Eremina O.G. Sostoyanie novorozhdennogo posle stimulyatsii rodov vnutrivennym vvedeniem oksitotsina [The state of the newborn after the stimulation of labor by intravenous administration of oxytocin]. Tez. dokl. 1-go sʺezda pediatrov i akusherov-ginekologov Tatarskoy ASSR. Kazan, 1988.
9. Persianinov L.S. Anomalii rodovoy deyatelʹnosti. V kn.: Akusherskiy seminar [Anomalies of labor. In the book: Obstetric workshop]. Tashkent, 1973. Vol. 2. Pp. 263-346.
10. Sadykov B.G., Voronin K.V. On the induction of labor according to the method of M.E. Barats. Kazanskiy med. zh, 1964, 4, pp. 94-95 (in Russ.).
11. Sadykov B.G., Voronin K.V. On the artificial induction of labor by G.M. Sharafutdinov and M.E. Barats. Kazanskiy med. zh, 1964, 5, pp. 107-109 (in Russ.).
12. Sadykov B.G., Gurevich P.S., Voronin K.V. Delivery of Rhesus-immunized women. Kazanskiy med. zh, 1967, 3, pp. 48-51 (in Russ.).
13. Sadykov B.G., Ignatʹeva D.P., Blokhina M.F., Podtyazhkina V.E. Rodorazreshenie, diagnostika i printsipy lecheniya gemoliticheskoy bolezni novorozhdennykh. Nauchnye trudy KGMI [Delivery, diagnosis and treatment of hemolytic disease of the newborn. Scientific works of KGMI]. Kazan, 1978. Vol. 50. Pp. 90-93.
14. Yakubova Z.N. Methods of stimulation of labor activity in the early discharge of water. Kazanskiy med. zh, 1965, 3, pp. 59-60 (in Russ.).
15. Florinskiy V.M. Kurs akusherstva, zapiski po lektsiyam ehkstraordinarnogo professora Vasiliya Markovicha Florinskogo [The course of obstetrics, notes on lectures by extraordinary professor Vasily Markovich Florinsky]. Saint Petersburg, 1872.
16. Bolondzʹ V.V. Klinicheskie i ehksperimentalʹnye nablyudeniya nad vnutrivennym gedonalovym narkozom. Sb. rabot po akusherstvu i ginekologii, posvyashch. prof. V.S. Gruzdevu 25-letiyu ego vrachebno-uchenoy deyatelʹnosti [Clinical and experimental observations on intravenous hedonal anesthesia. Sat works on obstetrics and gynecology, dedicated. prof. V.S. Gruzdev 25th anniversary of his medical and scientific activities]. Petrograd, 1917-1923.
17. Gruzdev V.S. Kurs akusherstva i zhenskikh bolezney. Ch. 2, T. 1. [Course of obstetrics and female diseases. Part 2, vol. 1]. Berlin, 1922. Pp. 271-274.
18. Kudashev A.D. Experience in the use of hypnosis in obstetrics and gynecology. Kazanskiy med. zh, 1927, 12, pp. 1253-1263 (in Russ.).
19. Dʹyakonov V.V., Chernoyarova V.D. Peculiarities of childbirth in the “old” primiparas. Kazanskiy med. zh, 1930, 4, pp. 367-383 (in Russ.).
20. Manenkov P.V., Romanov M.A. Obezbolivanie normalʹnykh rodov [Anesthesia normal childbirth]. Kazan, 1936. Pp. 52.
21. Syzganova K.N. On the issue of pain in childbirth. Kazanskiy med. zh, 1936, 9, pp. 1093-1094 (in Russ.).
22. Kolbasov I.S. Local anesthesia according to Vishnevsky during childbirth. Kazanskiy med. zh, 1938, 5-6, pp. 481-484 (in Russ.).
23. Danilov I.V. On lubricating cocaine sex points in the nose with dysmenorrhea and generic pain. Kazanskiy med. zh, 1937, 2 (in Russ.).
24. Sidorova L.S., Syzganova K.N. Pain relief childbirth in one of the ways prof. Lurie. Kazanskiy med. zh, 1939, 1, pp. 76-77 (in Russ.).
25. Sidorov N.E. On the effect of some painkillers on expulsive forces during childbirth. Akusherstvo i ginekologiya, 1937, 4, pp. 58-65 (in Russ.).
26. Sidorov N.E. Anesthesia of the belladonna genera in combination with pantopon, antipyrine and magnesium sulfate. Akusherstvo i ginekologiya, 1941, 1, pp. 36-38 (in Russ.).
27. Bakieva R.G. K voprosu o vliyanii nekotorykh rodoobezbolivayushchikh sredstv na vnutrennie organy materi i ploda v ehksperimente: avtoref. dis. … kand. med. nauk [To the question of the influence of some generic anesthetics on the internal organs of the mother and fetus in the experiment. Synopsis of dis. PhD med. sciences]. Kazan, 1946.
28. Korchagina N.A. O vliyanii nekotorykh obezbolivayushchikh sredstv na sokratitelʹnuyu sposobnostʹ matki v ehksperimente: avtoref. dis. … kand. med. nauk [On the effect of some painkillers on the contractility of the uterus in the experiment. Synopsis of dis. PhD med. sciences]. Kazan, 1947.
29. Banshchik F.Ya. Anesteziologicheskoe obespechenie rodov pri tyazhelykh formakh pozdnego toksikoza: avtoref. dis. … kand. med. nauk [Anesthetic management of childbirth in severe forms of late toxicosis. Synopsis of dis. PhD med. sciences]. Kazan, 1977.
30. Kozlov L.A., Polyakov I.F., Sevostʹyanov V.V., Kazemirov Eh.K. External electrostimulation of the uterus in the postpartum period. Kazanskiy med. zh, 1983, 3, pp. 231-232 (in Russ.).
31. Polyakov I.F., Kozlov L.A., Sevostʹyanov V.V., Kazemirov Eh.K. Opyt ispolʹzovaniya naruzhnoy ehlektrostimulyatsii v akusherstve i ginekologii [Experience of using external electrostimulation in obstetrics and gynecology]. Tez. dokl. KHIV Vsesoyuznogo sʺezda akusherov-ginekologov. Moscow, 1983.
32. Kozlov L.A., Polyakov I.F., Sevostʹyanov V.V. et al. External electrostimulation of the uterus for termination of pregnancy in the later periods. Kazanskiy med. zh, 1984, 5, pp. 363-364 (in Russ.).
33. Kozlov L.A., Polyakov I.F., Sevostʹyanov V.V., Kazemirov Eh.K. Prevention of increased blood loss in obstetric practice by external electrostimulation of the uterus. Kazanskiy med. zh, 1986, 6, pp. 425-427 (in Russ.).
34. Kozlov L.A., Polyakov I.F., Sevostʹyanov V.V., Kazimirov Eh.K. Naruzhnaya stimulyatsiya kak nemedikamentoznyy sposob usileniya tonomotornykh svoystv matki [External stimulation as a non-drug method of enhancing uterine tonomotor properties]. Materialy Plenuma Vsesoyuznogo obshchestva akusherov-ginekologov. Tashkent, 1986. Pp. 78-79.
35. Kozlov L.A., Polyakov I.F., Sevostʹyanov V.V. et al. K voprosu o nemedikamentoznom vyzyvanii rodov [On the issue of non-drug-induced induction of labor]. Tez. dokl. vtorogo sʺezda akusherov — ginekologov, i detskikh vrachey Chuvashskoy ASSR. Cheboksary, 1987. Ch. 1.
36. Kozlov L.A., Polyakov I.F., Nikonova L.V. et al. Naruzhnaya ehlektrostimulyatsiya matki u beremennykh i rozhenits pri tyazhelykh ehkstragenitalʹnykh zabolevaniyakh [ External electrostimulation of the uterus in pregnant women and women in childbirth in severe extragenital diseases]. Tez. dok. 1-go sʺezda pediatrov i akusherov-ginekologov TASSR. Kazan, 1988.
37. Kozlov L.A., Polyakov I.F., Nikonova L.V., Sevostʹyanov V.V. Naruzhnaya ehlektrostimulyatsiya matki. Metodicheskie ukazaniya dlya vrachey po diagnostike i lecheniyu nekotorykh zabolevaniy polovoy sfery u zhenshchin [External electrostimulation of the uterus. Guidelines for doctors on the diagnosis and treatment of certain diseases of the genital sphere in women]. Kazan, 1988.
38. Polyakov I.F., Sevostʹyanov V.V., Kazimirov Eh.K. et al. Naruzhnaya ehlektrostimulyatsiya kak metod preduprezhdeniya krovopoteri i materinskoy smertnosti [External electrostimulation as a method for preventing blood loss and maternal mortality]. Tez. dokl. KHV Vsesoyuznogo sʺezda akusherov – ginekologov. Donetsk, 1989.
39. Polyakov I.F., Yankovich V.A., Nikonova L.V. et al. Opyt naruzhnoy ehlektrostimulyatsii matki [Experience of external electrostimulation of the uterus]. Tez. nauchno-praktich. konf., posvyashchennoy 125-letiyu so dnya rozhdeniya zasluzhennogo deyatelya nauki, professora V.S. Gruzdeva. Kazan, 1991.