I.V. VAKHLOVA¹, N.A. ZYUZEVA^{1, 2}

¹The Ural State Medical University, Ekaterinburg
² Children’s city hospital №5, Ekaterinburg

 For correspondence:

Vakhlova I.V.– D. Med. Sc., Professor, Head of the Department of Hospital Pediatrics of  Ural State Medical University, 3 Repin Str., 620028, Ekaterinburg, tel. (343) 214-86-57, e-mail: [email protected]¹

The article presents the results of the analysis of health and vitamin D status among infants living in an industrial megalopolis. The study revealed a high frequency of low vitamin D level among infants (49.2 %); the best indicators of vitamin D supply were found among children of the first year of life. The authors emphasize the role of breast feeding and timely introduction of complementary foods in achieving a normal vitamin D level (OR = 5.2; ДИ 95 % [1.8 ÷ 14.4]). The results show a negative impact of infectious anamnesis of mothers during pregnancy on vitamin D provision of a child (OR = 2.4 ДИ 95 % [1.19 ÷ 4.85]). We noted the close connection between the low provision of vitamin D among infants and the increased incidence of acute respiratory diseases (OR = 10.7 ДИ 95 % [2.3 ÷ 48.8]). The optimal prophylactic dose of vitamin D providing normal levels of 25 (OH) D3 in the blood serum of infants is 1000 IU. The study proved the effectiveness of prescribing a prophylactic dose of vitamin D (500 IU) during 1 month for children of the third year of life to improve the vitamin D supply: disappearing of vitamin D deficiency, normalization of calcium metabolism. The results of the study contribute to an understanding of the clinical value of vitamin D and the development of new approaches to preventing vitamin D deficiency in children.

Key words: infants, vitamin D, serum 25(OH)D3 level.

REFERENCES

1. Gromova O.A., Torshin I.Yu. Vitamin D – smena paradigm [Vitamin D  –  paradigm shift]. Moscow: TORUS PRESS, 2015. 464 p.
2. Zakharova I.N., Mal’tsev S.V., Borovik T.E., Yatsyk G.V., Malyavskaya S.I., Vakhlova I.V. et al. Vitamin D deficiency in young children in Russia (results of a multicenter study – winter 2013-2014), Pediatriy, 2014, vol. 93, no. 2, pp. 75 – 80 (in Russ.).
3. Mattila P.H., Pirronen V.I. Uusi-Rauva E.J., Koivistoinen P.E., Vitamin D contents in edible mushrooms. J. Agric. Food Chem., 1994, no. 42, rr. 2449–2453.
4. Zakharova I.N., Korovina N.A., Dmitrieva Yu.A. The role of metabolites of vitamin D in rickets in children. Pediatriya, 2010, vol. 89, no. 3, pp. 68–73 (in Russ.).
5. Sundaram M.E., Coleman L.A. Vitamin D and influenza. Adv. Nutr., 2012, vol. 3, no. 4, rr. 517–525.
6. Lang P.O., Samaras D. Aging adults and seasonal influenza: Does the vitamin D status (h)arm the body? J. Aging Res., 12:806198. Doi:10.1155/2012/806198.
7. Profilaktika i lechenie rakhita u detey rannego vozrasta: metodicheskie rekomendatsii MZ SSSR, pod red. E.M. Luk’yanovoy [Prophylaxis and treatment of rickets in young children: methodical recommendations of the Ministry of Health of the USSR, Ed. by E.M. Lukyanova]. Moscow, 1990. 34 p.
8. Charzewska J, Chlebna-Sokol D, Chybicka A. Prophylaxis of vitamin D deficiency-Polish recommendation 2009. Endocrinol. Pol., 2010, no. 61, rr. 228-–232.
9. Takacs I., Benco I, Toldy E. Hungarian consensus regarding the role of vitamin D in the prevention and treatment of diseases. Orv Hetil., 201, 153, pp. 5–26.
10. German Nutrition Society. New reference values for vitamin D. Ann Nutr. Metab., 2012, no. 60, rr. 214-246.
11. Natsional’naya programma “Nedostatochnost’ vitamina D u detey i podrostkov Rossiyskoy Federatsii: sovremennye podkhody k korrektsii” (proekt) [National program «Vitamin D deficiency in children and adolescents of the Russian Federation: modern approaches to correction» (draft)]. Moscow, 2017.
12. Holick M.F., Binkley N.C., Bischoff-Ferrari H.A., Gordon C.M., Hanley D.A., Heaney R.P., Murad M.H., Weaver C.M. Evaluation, treatment, and prevention of vitamin D deficiency: An endocrine society clinical practice guidline. J. Clin. Endocrinol. Metab., 2011, no. 96, rr. 1911–1930.
13. Zakharova I.N., Klimov L.Ya., Gromova O.A. et al. The scheme of prevention and correction of vitamin D deficiency in young children: efficacy and safety of an aqueous solution of cholecalciferol. Consilium Medicum. Pediatriya (Pril.), 2016,  no.  04, rr. 86–93 (in Russ.).
14. Nasybullina G.M., Kocheva N.Shch., Sannikova N.E., Vakhlova I.V Otsenka fizicheskogo razvitiya detey Sverdlovskoy oblasti ot 0 do 16 let (Metodicheskie rekomendatsii) [An estimation of physical development of children of Sverdlovsk area from 0 to 16 years (Methodical recommendations)].  Ekaterinburg: izd-vo UGMU, 2002. 83 p.
15. Tits N. U. Entsiklopediya klinicheskikh laboratornykh testov [Encyclopedia of Clinical Laboratory Tests]. Moscow: Labinform, 1997. 960 p.
16. Sosnin D.Yu., Nenasheva O.Yu. Laboratory monitoring of the prevention of rickets in children by the results of urinalysis. Meditsinskiy alfavit. Sovremennaya laboratoriya, 2013, no. 3, pp. 54–56 (in Russ.).
17. Kel’manson I.A. Klinicheskaya epidemiologiya v pediatrii. Rukovodstvo [Clinical epidemiology in pediatrics. Management]. Saint Petersburg: SOTIS, 2001. 208 p.