Vitamin D metabolites: their role in the diagnosis and therapy of vitamin-D-dependent pathology
O.A. GROMOVA1, I.Yu. TORSHIN2, I.K. TOMILOVA1, A.V.GILEL1
1Ivanovo State Medical Academy of the Ministry of Health of the Russian Federation
2Moscow Institute of Physics and Technology (State University)
For correspondence:
Gromova O.A. – D. Med. Sc., Professor of the Department of Pharmacology and Clinical Pharmacology of Ivanovo State Medical Academy, 8 Sheremetevskiy prospekt, 153000 Ivanovo, tel. (4932) 41-65-25, e-mail: unesco.gromova@gmail.com
In most studies on the relationship between vitamin D and diseases, only one of the metabolites of vitamin D-25-hydroxyvitamin D3 (25 (OH) D3) is studied. In this case, the potential effects of levels of other metabolites of vitamin D remain outside the attention of most researchers. In the present work, biotransformation of cholecalciferol, possible errors in estimation of deficiency D (associated with the properties of various metabolites of vitamin D3), the fundamental biological role of vitamin D3 metabolites and prospects for using vitamin D3 metabolite levels for clinical diagnosis are considered.
Key words: metabolites of vitamin D, diagnosis of hypovitaminosis D, Aquadetrim.
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