Ultrasonic shear wave elastography and laboratory indicators in diagnosing and evaluating the effectiveness of nonalcoholic fatty liver disease treatment
M.G. TUKHBATULLIN1, A.E. YANGURAZOVA1,2, Z.M. GALEEVA1
1Kazan State Medical Academy — Branch Campus of the FSBEI FPE RMACPE MOH Russia, 36 Butlerov Str., Kazan, Russian Federation, 420012
2Medical Sanitary Unit of Kazan State University, 1A Chekhov Str., Kazan, Russian Federation, 420012
Tukhbatullin M.G. — D. Med. Sc., Professor, Head of the Department of Ultrasound Diagnostics, tel. +7-843-231-20-09, e-mail: munir.tuhbatullin@tatar.ru
Yangurazova A.E. — post-graduate student of the Department of Ultrasound Diagnostics, doctor, tel. +7-987-413-67-23, e-mail: aleksandra7891@bk.ru
Galeeva Z.M. — Cand. Med. Sc., Associate Professor of the Department Hospital and Policlinic Therapy, tel. (843) 236-87-86, e-mail: zarina26@bk.ru
The diagnosis of diffuse liver diseases, in particular the nonalcoholic fatty liver disease (NAFLD), is largely determined by methods that are informative, safe, non-invasive and can be used for all patients. One of these methods is shear wave elastography. To study these issues, a literature review was carried out; data on NAFLD risk factors, pathogenesis, and clinic are presented; the possible options for invasive and non-invasive diagnosing of NAFLD are described. Based on the results of own research in age-gender groups in patients with NAFLD, biochemical parameters and shear wave elastography data were evaluated. A direct correlation was found between the indicators of liver stiffness and age, presence of diabetes mellitus type 2, biochemical parameters, NAFLD and AST/ALT indices. The use of shear wave elastography, in combination with laboratory parameters and risk assessment by indices, enables to improve the diagnosing and efficiency evaluation of NAFLD treatment.
Key words: nonalcoholic fatty liver disease, steatosis, steatohepatitis, fibroscan, shear wave elastography.
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