A.V. TKACHEV, L.S. MKRTCHIAN, K.E. MAZOVKA, A.S. MAKARENKO, A.M. ASLANOV

Rostov State Medical University,  Rostov-on-Don

 Contact details:

Tkachev A.V. — MD, Professor, Head of the Department of Propaedeutics of Internal Diseases

Address: 29 Nakhichevanskiy per., Russian Federation, Rostov-on-Don, tel.: +7-918-557-11-73, e-mail: [email protected]

The article presents a review of modern literature on progress in the study of genetic factors predisposing to the development of inflammatory bowel disease (IBD). The research data of the recent years are summarized, which are related to genome-wide associations study (GWAS): gene-coding changes, direct violations by the neighboring zones of transcription factor links, and specific tissue epigenetic mechanisms; features of genes polymorphism are described for the territories of the Russian Federation. Many studies indicate the possibility of genetic variants that can be the basis for determining the mechanisms of the disease and, in the future, using genetic studies in the differential diagnosis of IBD, predicting the character and severity of the disease, and personalized medication treatment. However, it is necessary to remember that the presence of a genetic predisposition does not indicate the presence of a disease. This in turn emphasizes the influence of other factors on the development of IBD, such as environmental factors, nutritional characters, the influence of microbiota, which opens future direction for further studies of the interaction of the above factors and the practical use of the results.

Key words: ulcerative colitis, Crohn’s disease, inflammatory bowel disease, genes polymorphism.

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