O.N. LEVANOVA¹, V.A. SOKOLOV¹, V.G. LIKHVANTSEVA², A.A. NIKIFOROV¹, S.A. BEZRUCHKO³

¹Ryazan State Medical University named after Acad. I.P. Pavlov, 9 Vysokovoltnaya Str., Ryazan, Russian Federation, 390026

²Institute of Advanced Training of Federal Medical-Biological Agency of Russia, 91 Volokolamskoye shosse, Moscow, Russian Federation, 125371

³Clinical Hospital named after N.A. Semashko, 3 Semashko Str., Ryazan, Russian Federation, 390005

 Levanova O.N. ― full-time postgraduate student of the Department of Ocular and ENT Diseases, tel. +7-920-631-86-71, e-mail: Levanova.olga2013@yandex.ru

Sokolov V.A. ― D. Med. Sc., Professor of the Department of Ocular and ENT Diseases, е-mail: sva_sva@mail.ru

Likhvantseva V.G. ― D. Med. Sc., Professor of the Department of Ophthalmology, e-mail: likhvantseva-4@yandex.ru

Nikiforov A.A. ― Associate Professor of Pharmacology Department, Head of the Central Scientific Research Laboratory, e-mail: alnik003@yandex.ru

Bezruchko S.A. ― doctor of functional diagnostics, e-mail: Bezz75@mail.ru

 The article presents the results of examining of 66 patients with newly diagnosed primary open-angle glaucoma (POAG) (120 eyes) and 25 patients of the control group (50 eyes). Ophthalmic examination was complemented with genetic analysis. Concentration of MMP-9 in the lacrimal fluid in both eyes was determined with «sandwich» ELISA. Genetic analysis was performed with polymerase chain reaction. Single-nucleotide polymorphisms (SNPs) of the gene СFН (complement factor H) were studied. We found the correlation between the MMP-9 production and the genotype СFH, as well as the prevalence of CFH gene polymorphism in patients with POAG in general.

Key words: glaucoma, matrix metalloproteinase-9, lacrimal fluid, complement factor H.

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