A.R. GALLYAMOV^1-3, R.F. MASGUTOV^1-3, I.G. KHANNANOVA¹, R.I. MULLIN¹, А.А. SHULMAN¹, I.F. AKHTYAMOV^1,3, A.P. KIYASOV², A.A. BOGOV¹

¹Republic Clinical Hospital of the MH of RT, 138 Orenburgskiy trakt, Kazan, Russian Federation, 420064

²Kazan (Volga region) Federal University, 18 Kremlevskaya St., Kazan, Russian Federation, 420008

³Kazan State Medical University, 49 Butlerov St., Kazan, Russian Federation. 420012

Gallyamov A.R. — doctor of Traumatology Department № 2, postgraduate student of Traumatology, Orthopedics and Emergency Surgery Department, tel. (843) 237-34-25, e-mail: [email protected]

Masgutov R.F. — Сand. Med. Sc., doctor of Traumatology Department № 2, tel. (843) 237-34-25, e-mail: [email protected]

Khannanova I.G. — Сand. Med. Sc., doctor of Traumatology Department № 2, tel. (843) 237-34-25, e-mail: [email protected]

Mullin R.I. — Сand. Med. Sc., doctor of Traumatology Department № 2, tel. (843) 237-34-25, [email protected]

Shaulman A.A. — Cand. Biol. Sc., Senior Researcher, tel. (843) 237-34-25, e-mail: a[email protected]

Akhtyamov I.F. — D. Med. Sc., Head of Traumatology, Orthopedics and Emergency Surgery Department, tel. (843) 237-91-78, e-mail: [email protected]

Kiyasov A.P. — D. Med. Sc., Leading Researcher, tel. (843) 236-78-92, e-mail: [email protected]

Bogov A.A. — D. Med. Sc., Head of Traumatology Department № 2, tel. (843) 237-34-25, e-mail: [email protected]

The article reviews the basic principles of treatment of peripheral nerve injuries. The effects are described of injecting the autologous cells of stromal vascular fraction into the nervous tissues. The clinical cases and treatment results of curing the peripheral nerve injuries with autologous cells of stromal vascular fraction are described.

Key words: peripheral nerve injury, stem cells of stromal vascular fraction.

 

 

REFERENCES

1. Noble J., Munro C.A., Prasad V.S., Midha R. Analysis of upper and lower extremity peripheral nerve injuries in a population of patients with multiple injuries. Am J Phys Med Rehabil. J Trauma, 1998, Jul., vol. 45(1), rr. 116-22.
2. McAllister R., Gilbert S., Calder J., Smith P. The epidemiology and management of upper limbperipheral nerve injuries in modern practice. J Hand Surg [Br], 1996, vol. 21(1), rr. 4-13.
3. Karol A.G. Peripheral nerves and Tendon Transfers. Selected Reading in Plastic Surgery, 2003, vol. 9, r. 23.
4. Manders E.K., Saggers G.C., Diaz-Alonso P., Finn L., Sipio J.C., Glumac T., Au V.K., Wong R.K., Mottaleb MClin Plast Surg. Elongation of peripheral nerve and viscera containing smooth muscle., 1987, Jul., vol. 14(3), rr. 551-62.
5. Berger A., Millesi H. Nerve grafting. Clin Orthop Relat Res., 1978, vol. 133, rr. 49-55.
6. Bogov A.A. Khirurgicheskoe lechenie povrezhdeniy verkhney konechnosti s primeneniem metoda mikrokhirurgii i apparata Ilizarova: avtoref. dis. … d-ra med. nauk [Surgical treatment of upper limb injuries using the method of microsurgery and Ilizarov. Synopsis of dis. Dr Med. sci]. Moscow, 1997. 427 p.
7. Sandra A. Acosta, Naoki Tajiri, Kazutaka Shinozuka, Hiroto Ishikawa, Paul R. Sanberg, Juan Sanchez-Ramos, Shijie Song, Yuji Kaneko, Cesar V. Borlongan Combination Therapy of Human Umbilical Cord Blood Cells and Granulocyte Colony Stimulating Factor Reduces Histopathological and Motor Impairments in an Experimental Model of Chronic Traumatic Brain Injury. doi: 10.1371/journal.pone.0090953. Published: March 12, 2014.
8. Lu Chen, Ronald Coleman, Ronika Leang, Ha Tran, Alexandra Kopf, Craig M. Walsh, Ilse Sears-Kraxberger, Oswald Steward, Wendy Bcklin, Jeanne F. Loring, Thomas E. Lane. Human Neural Precursor Cells Promote Neurologic Recovery in a Viral Model of Multiple Sclerosis. Stem Cell Research & Therapy 2014. Published online 2014 May 15. doi: 10.1016/j.stemcr.2014.04.005.
9. Katare R., Stroemer P., Hicks C., Stevanato L., Patel S., Corteling R., Miljan E., Vishnubhatla I., Sinden J., Madeddu P. Clinical-grade human neural stem cells promote reparative neovascularization in mouse models of hindlimb ischemia. Arterioscler Thromb Vasc Biol., 2014, Feb., vol. 34(2), rr. 408-18. doi: 10.1161/ATVBAHA.113.302592. Epub 2013 Nov 7.
10. Yang D.Y., Sheu M.L., Su H.L., Cheng F.C., Chen Y.J., Chen C.J., Chiu W.T., Yiin J.J., Sheehan J., Pan H.C. J Neurosurg., 2012, Jun., vol. 116(6), rr. 1357-67. doi: 10.3171/2012.2.JNS111360. Epub 2012 Apr 13.
11. Wang D., Liu X.L., Zhu J.K., Jiang L., Hu J., Zhang Y., Yang L.M., Wang H.G., Yi J.H. Bridging small-gap peripheral nerve defects using acellular nerve allograft implanted with autologous bone marrow stromal cells in primates. Brain Res., 2008, Jan 10, vol. 1188, rr. 44-53. Epub 2007 Oct 18.
12. Spejo A.B., Carvalho J.L., Goes A.M., Oliveira A.L. Neuroprotective effects of mesenchymal stem cells on spinal motoneurons following ventral root axotomy: synapse stability and axonal regeneration. Neuroscience, 2013, Oct 10, vol. 250, rr. 715-32. doi: 10.1016/j.neuroscience.2013.07.043. Epub 2013 Jul 27.
13. Reid A.J., Sun M., Wiberg M., Downes S., Terenghi G., Kingham P.J. Nerve repair with adipose-derived stem cells protects dorsal root ganglia neurons from apoptosis. Neuroscience, 2011, Dec 29, vol. 199, rr. 515-22. doi: 10.1016/j.neuroscience.2011.09.064. Epub 2011 Oct 6.
14. Marconi S., Castiglione G., Turano E., Bissolotti G., Angiari S., Farinazzo A., Constantin G., Bedogni G., Bedogni A., Bonetti B. Human adipose-derived mesenchymal stem cells systemically injected promote peripheral nerve regeneration in the mouse model of sciatic crush. Tissue Eng Part A, 2012, Jun., vol. 18(11-12), rr. 1264-72. doi: 10.1089/ten.TEA.2011.0491. Epub 2012 Apr 3.
15. Masgutova G.A., Masgutov R.F., Salafutdinov I.I., Shul’man A.A., Zhuravleva M.N., Gallyamov A.R., Bogov A.A. (mlad.), Bogov A.A., Rizvanov A.A. Stimulation of posttraumatic regeneration of the sciatic nerve in the rat xenotransplantation of multipotent mesenchymal stromal cells of human adipose tissue. Geny&Kletki, 2014, vol. IX, no. 3 (in Russ.).