K.V. MUZUROV, Yu.Sh. KHALIMOV, A.V. FOMICHOV, O.V. VETRYAKOV

Military Medical Academy named after S.M. Kirov, 17/A Botkinskaya St., Saint-Petersburg, Russian Federation, 194044

Muzurov K.V. ― adjunct of the Department of military field therapy, tel. +7-921-595-02-15, e-mail: conzze@mail.ru

Khalimov Yu.Sh. ― D. Med. Sc., Professor, Head of the Department of military field therapy, tel. +7-921-941-18-56, e-mail: yushkha@gmail.com

Fomichov A.V. ― Cand. Med. Sc., senior lecturer of the Department of military field therapy, tel. +7-921-361-97-17, e-mail: fomichoff74@mail.ru

Vetryakov O.V. ― Cand. Med. Sc., lecturer of the Department of military field therapy, tel. +7-911-014-47-74, e-mail: o.v.vetryakov@mail.ru 

The article deals with the clinical aspects of acute poisoning with isoniazid ― primary anti-TB drug. Acute intoxication with the drug is manifested in repeating generalized tonic clonic seizures, severe metabolic acidosis and coma. This article describes a clinical case of severe acute poisoning with isoniazid with suicidal purpose, which was accompanied by all the classic symptoms ― convulsions, depression of consciousness and acidosis. After ingesting 7,5 g of isoniazid, a 29-year-old female was transferred to a hospital with depression of consciousness and convulsive attacks. The exposure lasted for 2.5 hours. The patient underwent a complex of therapeutic measures, including probe gastric lavage, introduction of enterosorbent, forced dieresis, antidotal, symptomatic and pathogenetic therapy. She was extubated after 14 hours post-overdose. No complications from the organs and systems. The patient is fully recovered.

Key words: isoniazid; overdose; poisoning; seizure, acidosis, depression of consciousness.

 

 

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