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  • Substantiating the necessity of integrating drugs with cytokine-inhibiting action into complex therapy of pancreatic necrosis  

    Редактор | 2017, Original articles, Practical medicine 06 (17) Surgery | 21 сентября, 2017

    V.A. GORSKIY, M.V. KHOREVA, M.A. AGAPOV, V.P. ARMASHOV

    Pirogov Russian National Research Medical University, 1 Ostrovityanov Str., Moscow, Russian Federation, 117997

    Gorskiy V.A. — D. Med. Sc., Professor, Head of the Department of Experimental and Clinical Surgery, tel. +7-903-218-81-81, e-mail: [email protected]

    Khoreva M.V. — D. Med. Sc., Professor of the Department of Immunology, tel. +7-916-294-01-67, e-mail: [email protected]

    Agapov M.A. — D. Med. Sc., Professor of the Department of Experimental and Clinical Surgery, tel. +7-916-365-79-20, e-mail: [email protected]

    Armashov V.P. — Cand. Med. Sc., Associate Professor of the Department of Experimental and Clinical Surgery, tel. 8-916-754-29-23, e-mail: [email protected]

    The authors have found significant variations in the functional activity parameters of the TLR system in patients with PN depending on the disease severity. These indicators can be used as a target for therapeutic treatment. Antimediatory therapy with NSAID “Lornoxicam” in the course of this research resulted in considerable improvement of the outcomes of medical treatment of the patients with PN.

    Key words: pancreatic necrosis (PN), cytokines, Toll-like receptors (TLR), NSAIDs (non-steroidal anti-inflammatory drugs), antimediatory treatment.

    References

    1. Weber C.K., Adler G. From acinar cell damage to systemic inflammatory response: current concepts in pancreatitis // Pancreatology. – 2001. – Vol. 1. – P. 356–362.
    2. Novovic S., Andersen A.M., Ersboll A.K., Nielsen O.H. et al. Proinflammatory cytokines in alcohol or gallstone induced acute pancreatitis. A prospective study // Journal of Pancreas. – 2009. – Vol. 10 (3). – P. 256–261.
    3. Hietaranta A., Mustonen H., Puolakkainen P., Haapiainen R., Kemppainen E. Proinflammatory effects of pancreatic elastase are mediated trough TLR4 and NF-kB // Biochem. Biophys. Res. Commun. – 2004. – Vol. 323 (1). – P. 192–196.
    4. Hong-Geller E., Chaudhary A., Lauer S. Targeting toll-like receptor signaling pathways for design of novel immuno therapeutics // Curr. Drug. Discov. Technol. – 2008. – Vol. 5 (1). – P. 29–38.
    5. Berg J., Fellier H., Christoph T., Grarur J., Strimmeder D. The analgesic NSAID lornoxican inhibits cyclooxygenase (COX)-1/2, inducible nitric oxide synthase (iNOS), and the formation of interleukin(IL)-6 in vitro // Inflamm. Res. – 1999. – Vol. 48. – P. 369–379.
    6. Yin J., Huang Z., Xia Y. et al. Lornoxicam suppresses recurrent herpetic stromal keratitis through down-regulation of nuclear factor-kB: an experimental study in mice // Molecular Vision. – 2009. – Vol. 15. – P. 1252–1259.
    7. Gorskiy V., Agapov M., Khoreva M., Leonenko I. Antimediator therapy as a part of the complex treatment of acute destructive pancreatitis // Abstracte 43rd European Pancreatic Club (EPC) Meeting, Magdeburg, June 22 – 25, 2011. – 2011. – р.178.
    8. Kovalchuk L., Gorskiy V., Khoreva M., Agapov M. et. al. TRL2 and TRL4 expression in peripheral blood mononuclear cells of the patients with acute destructive pancreatitis // Cytokines and inflammation. – 2012. – Vol. 11. – № 4.– P.50–56.
    9. Gorskiy V., Agapov M., Khoreva M., Leonenko I. Estimating the possibility of antimediator therapy to influence on matrix RNA expression in molecular blood cells of the patients with acute destructive pancreatitis // Journal of Experimental and Clinical Surgery. – 2012. – Vol. 5. – № 2. – P. 268–272.

    Метки: 2017, antimediatory treatment, cytokines, M.A. AGAPOV, M.V. KHOREVA, NSAIDs (non-steroidal anti-inflammatory drugs), pancreatic necrosis (PN), Practical medicine 06 (17) Surgery, Toll-like receptors (TLR), V.A. GORSKIY, V.P. ARMASHOV

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