Yu.A. DYLEVA¹, O.V. GRUZDEVA^1,2, E.G. UCHASOVA¹, V.V. KASHTALAP^1,2

 ¹ Scientific and Research Institute for Complex Problems of Cardiovascular Diseases, 6 Sosnovy boulevard Str., Kemerovo, Russian Federation, 650002

² Kemerovo State Medical University of the Ministry of Health of the Russian Federation, 22a Voroshilova Str., Kemerovo, Russian Federation, 650056

 Dyleva Yu.A. — Ph. D. (medicine), Research Associate of the Laboratory for Research of Homeostasis, tel. +7 (3842) 64-05-53, email: [email protected]

Gruzdeva O.V. — D. Sc. (medicine), Head of the Laboratory for Research of Homeostasis, Associate Professor of the Department of Pathological Physiology, Medical and Clinical Biochemistry, tel. +7 (3842) 64-05-53, email: [email protected]

Uchashova E.G. — Ph. D. (medicine), Senior Research Associate of the Laboratory for Research of Homeostasis, tel. +7 (3842) 64-05-53, email: [email protected]

Kashtalap V.V. — D. Sc. (medicine), Head of the Laboratory of Pathophysiology, Associate Professor of the Department of Cardiology and Cardiovascular Surgery, tel. +7 (3842) 64-31-53, email: [email protected]

 The work is devoted to assessing the level of ST2 in the dynamics of the hospital period and the study of its relationship with the development of early complications of myocardial infarction (MI).

Material and methods. The study included 88 patients with MI at the age of 59±8,36 years. On the 1st and 12th days of the development of the disease in the serum, the content of ST2 and NT-proBNP was determined using the enzyme immunoassay method. The control group consisted of 30 people. Statistical data processing was performed using the software package STATISTICA 6.1. and SPSS 17.0 for Windows.

Results. The level of ST2 and NT-proBNP in patients with hospital complications of MI was 3,7 and 1,8 times, respectively, higher than the control group on day 1 and higher, compared to the group of patients with a favorable course of MI in 2 and 6,8 times, respectively. By the 12th day, the content of ST2 decreased, and NT-proBNP remained elevated in both study groups. Logistic regression analysis showed a high diagnostic value for determining the level of ST2 (OR 1,7; 95% CI (1,6–2,8) AUC is 0,78, p=0,003) compared to NT-proBNP (OR 1,2; 95% CI (1,1–1,6) AUC is 0,69, p=0,034) in assessing the development of hospital complications of MI. The combined use of these markers increased the diagnostic sensitivity and specificity (OR 1,92; 95% CI (1,7–3,2) AUC is 0,89, p=0,004).

The conclusion. A more sensitive indicator of the course of the hospital period of MI is the level of ST2, compared with NT-proBNP. High diagnostic sensitivity and specificity of the combined use of ST2 and NT-proBNP were revealed.

Key words: stimulating growth factor ST2, N-terminal pro-brain natriuretic peptide (NT-proBNP), myocardial infarction, hospital complications of myocardial infarction, prognosis of myocardial infarction, risk stratification.

 (For citation: Dyleva Yu.A., Gruzdeva O.V., Uchashova E.G., Kashtalap V.V. Stimulating growth factor ST2 – a new marker of risk stratification of hospital complication of myocardial infarction. Practical Medicine. 2018)

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