G.N. AFLYATUMOVA¹, D.I. SADYKOVA², R.R. NIGMATULLINA³, Z.M. SHAGVALEEVA¹, M.D. CHIBIREVA³, E.V. SERGEEVA³, G.R. HUSNUTDINOVA⁴ , Y.M. CHILIKINA⁵

 ¹Children’s Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan, 140 Orenburgskiy Trakt, Kazan, Russian Federation, 420138

²Kazan State Medical Academy, 36 Butlerov Str., Kazan, Russian Federation, 420012

³Kazan State Medical University, 49 Butlerov Str., Kazan, Russian Federation, 420012

⁴City Clinical Hospital No. 7, 54 Marshal Chuykov Str., Kazan, Russian Federation, 420103

⁵City Children’s Polyclinic No.7, 48 Prospect Yamasheva, Kazan, Russian Federation, 420126

Aphlyatumova G.N. — cardiologist, tel. +7-987-296-75-36, e-mail: aflyatumovagulfia@mail.ru

Sadykova D.I. — D. Med. Sc., Head of the Department of Pediatrics with a course of an outpatient pediatrics, tel. (843) 237-30-37, e-mail: sadykovadi@mail.ru

Nigmatullina R.R. — Doctor of Biological Sciences, Professor of the Department of Physiology, tel.+7-927-429-04-66, e-mail: razinar@mail.ru

Shagvaleeva Z.M. — cardiologist, tel. 261-40-57, e-mail: zshagvaleeva@mail.ru

Chibireva M.D. — student, tel. +7-987-293-39-17, e-mail: chamomilla725@yandex.ru

Sergeeva E.V. — laboratory assistant of the Department of Hospital Pediatrics with cources of PE and PAE, tel. +7-919-620-02-62, e-mail: evs131@mail.ru

Khusnutdinova G.R. — Head of the immunological laboratory, tel. (843) 221-36-71, e-mail:gkb7@bk.ru

Chilikina Yu.M. — doctor of functional diagnostics, tel. +7-917-891-42-03, e-mail: juliakazan@list.ru

The article contains data about the state of vasoactive mediators in adolescents with different clinical andfunctional versions of essential hypertension. In children is marked increasing concentration of endothelin in plasma and serotonin in serum which is dependent on level of arterial pressure. At the same time differently directed indicators of nitric oxide and serotonin in patient’s blood platelets are revealed depending on the stage of the disease, which indicates the activation of compensatory-adaptive mechanisms already in the early stages of hypertension development. In the course of the process aggravation secondary mechanisms of compensation are activated due to chronic hyperactivation of vasomediator systems.

Key words: essential arterial hypertension, adolescents, endothelin, serotonin, nitric oxide.

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