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  • State of the innate immunity of the buccal cavity in pregnant women with dental caries 

    Редакция | 2014, Original articles, Practical medicine 07 (14) Infectious diseases. Antimicrobial therapy | 7 октября, 2014

    V.A. PROKHODNAYA1, T.V. GAYVORONSKAYA2, S.О. SURMENOVA2

    1Kuban State Medical University, 4 Sedina St., Krasnodar, Russian Federation, 350063

    2Rostov State Medical University, 29 Nakhichevanskiy per., Rostov-on-Don, Russian Federation, 344718

    Gayvoronskaya TV. — D. Med. Sc., Professor, Head of the Department of Surgical Stomatology and Maxillofacial Surgery, Vice Rector on Educational and Pedagogical Work, tel. (861) 268-54-83, e-mail: T.Gaivoronskaya@rambler.ru1

    Prokhodnaya V.A. — Cand. Med. Sc., Associate Professor of the Department of Stomatology № 1, tel. (863) 250-41-98, e-mail: ms.victoria111@mail.ru2

    Surmenova S.O. — postgraduate student of the Department of Stomatology № 1, tel. (863) 250-41-98, e-mail: ms.victoria111@mail.ru2

    The paper presents the results of measurement of antimicrobial protein lactoferrin and antibacterial peptides defensins and сatelicidins in the oral fluid in 207 pregnant women with caries at various stages of gestational period. The control groups were healthy non-pregnant women (n=32) and healthy pregnant women without caries (n=31). The results of the study showed that pregnant women showd a steady increase of lactoferrin and сatelicidinLL37 in oral fluid during gestational period, which prevents the development of caries. However, reliable changes in the levels of defensins 1-3 in dynamics were not observed. The development of dental caries during pregnancy was associated with increases in the level of all three studied factors of innate immunity the mouth in the 2nd trimester, followed by a decline of defensins 1-3 and catelicidin LL37 in oral fluid. Therefore, the depletion of the reserves of the secretion defensins-1-3 and catelicidin LL37 by epithelial cells and neutrophils in the oral cavity contributed to the development of caries.

    Key words: pregnancy, dental caries, oral fluid, antimicrobial protein, antibacterial peptides.

     

     

    REFERENCES

    1. Kulakova E.V., Elizarova V.M., Pampura A.N., Vinogradova T.V., Varlamov E.E. The role of endogenous antimicrobial peptides (cathelicidin LL-37) in the development of dental caries in children with atopic dermatitis. Lechenie i profilaktika, 2013, no. 1, pp. 73-76 (in Russ.).

    2. Aleshina G.M., Kokryakov V.N., Shamova O.V., Orlov D.S. et al. Innovative concept of antimicrobial peptides as molecular factors immunity. Meditsinskiy akademicheskiy zhurnal, 2010, no. 4, pp. 149-160 (in Russ.).

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    5. Ivanyushko T.P., Gankovskaya L.V., Shamanaev S.V., Svitich O.A. et al. Studying the content of defensins in patients with purulent-inflammatory diseases of the maxillofacial area. Stomatologiya, 2014, no. 2, pp. 23-26 (in Russ.).

    6. Kim J.Y., Park S.C., Hwang I., Cheong H. et al. Protease inhibitors from plants with antimicrobial activity. Int. J. Mol. Sci., 2009, vol. 10, p. 2860.

    7. Makeeva I.M., Smirnova T.N., Chernousov A.D., Romanchenko A.I. et al. Application of lactoferrin in the complex treatment of dental diseases (literature review). Stomatologiya, 2012, no. 4, pp. 66-71 (in Russ.).

    8. Durnovo E.A., Vorob’eva A.V., Bespalova N.A., Klochkov A.S. et al. Diagnostic possibilities of oral fluid dynamics of lactoferrin for the assessment of the early postoperative period in surgical interventions in the oral cavity. Meditsinskiy al’manakh, 2012, no. 2, pp. 242-246 (in Russ.).

    Метки: antibacterial peptides, antimicrobial protein, dental caries, oral fluid, Practical medicine 07 (14) Infectious diseases. Antimicrobial therapy, pregnancy, S.О. SURMENOVA, T.V. GAYVORONSKAYA, V.A. PROKHODNAYA

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