N.Kh. GABITOVA, S.I. ZHDANOVA, I.N. CHEREZOVA, E.M. NEMIROVSKAYA, M.S. CHERNYKH

Kazan State Medical University of the Ministry of Health of the Russian Federation, Kazan

Republican Clinical Hospital of the Ministry of Health of Tatarstan Republic, Kazan

Contact:

Gabitova N.Kh: PhD (medicine), Associate Professor of the Department of Hospital Pediatrics

Address: 140 Orenburgskiy trakt, 420138 Kazan, Russian Federation, tel. (843) 237-35-37, e-mail: borismk1@rambler.ru

Congenital leukemia is a rare disease in the neonatal period. The difficulty of diagnosing this pathology is determined by its similarity with a number of other diseases of the neonatal period, such as sepsis, cytomegalovirus infection, congenital hepatitis, erythroblastosis, etc. The presented clinical case shows characteristic diagnostic criteria for congenital leukemia in a newborn child, the speed and aggressive nature of its course.

Key words: congenital leukemia, newborn child, leukemids.

REFERENCES

1. Howlader N., Noon A.M., Krapcho M. et al. SEER Cancer Statistics Review, 1975-2010, Bethesda; National Cancer Institute.   2013.
2. Hafiz M.G., Khaleque M.A. Congenital Acute Lymphoblastic Leukemia: A Rare Presentation in a One Month Old Boy. PediatTherapeut., no. 4, p. 204. doi:10.4172/2161-0665.1000204
3. Bogadel’nikov I.V., Usova S.V., Dyabina T.A. et al. A case of acute leukemia in a young child. Zdorov’e rebenka, 2013, no. 2 (45), pp. 121-127 (in Russ.).
4. Greaves M.F., Maia A.T., Wiemels J.L., Ford A.M. Leukemia in twins: lessons in natural history. Blood, 2003, no. 102, pp. 2321-2333.
5. Maschan M.A., Mayakova N.V. Acute lymphoblastic leukemia in children. Onkogematologiya, no. 1 (2), 2006, pp. 50-63.
6. Kislyak N.S., Makhonova L.A., Ivanovskaya T.E. Klinicheskoe techenie ostrogo leykoza u detey [The clinical course of acute leukemia in children]. Moscow, 1972. 127 p.
7. Chowdhury T. et al. Insights from clinical studies into the role of the MLL gene in infant and childhood leukemia. Blood Cells Mol Dis., 2008. Mar-Apr, available at: http//www.ncbi.nlm.gov/pubmed/8025282
8. Pui C.H., Chessels J.M., Camitta B. et al. Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11 q 23 rearrangements. Review article. Leukemia, 2003, no. 17 (4), pp. 700-706, available at: http//www.ncbi.nlm.gov/pubmed/12682627
9. Tsaur G.A., Meyer C., Popov A.M. et al. Study of structural chimeric genes with the participation of the MLL gene in acute leukemia in children of the first year of life. Gematologiya i transfuziologiya, 2014, vol. 59, no. 1, pp. 29-37 (in Russ.).
10. Panina O.V., Semenova E.V., Markova I.V. et al. Modern views on the treatment of acute leukemia in children 1 year old. Rossiyskiy zhurnal Detskoy gematologii i Onkologii, 2019, vol. 2 (in Russ.).
11. Doumbia M., Uwingabiye J., Bissan A. et al. Epidemiological, clinical, cytologic and immunophenotypic aspects of acute leukemia in children: the experience at the hematology laboratory of IBN SINA University Hospital Center, 2016, no. 23, p. 258. doi:10.11604/pamj.2016.23. 258.8396.eCollection 2016.
12. Brethon B., Cave H., Fahd M., Baruchel A. Infant acute leukemia. Bull Cancer, 2016, no. 103 (3), pp. 299-311. doi:10. 1016/j.bulcan 2015. 11.009. Epub 2016 Jan 27.
13. Kolenkova G.V. Markers of acute leukemia in the diagnosis of a disease in children. Gematologiyaitransfuziologiya, 2002, no. 2, pp. 28-35 (in Russ.).
14. Trofimova I.Sh., Fazleeva L.K., Cherezova I.N. VCongenital leukemia in children. Kazanskiy meditsinskiy zhurnal, 2001, no. 5, pp. 353-356 (in Russ.).
15. Drozdov A.A., Drozdova M.V. Zabolevaniya krovi: polnyy spravochnik: Polnaya klassifikatsiya. Mekhanizmy razvitiya. Samye sovremennye metody diagnostiki i lecheniya [ Blood Diseases: A Complete Guide: Complete Classification. Development mechanisms. The most modern methods of diagnosis and treatment]. Moscow: EKSMO, 2008. 608 p.
16. Biondi A., Cimino G., Pieters R. et al. Biological and therapeutic aspects of infant leukemia. Blood, 2000, vol. 96, no. 1, pp. 23-34.
17. Marchesi F., Girardi K., Avvisati G. Pathogenetic, clinical and prognostic features of adult t(4;11)(q21;q23)/MLL-AF4 positive B-cell acute lymphoblastic leukemia. AdvHematol, 2011, pp. 1-8. doi: 10.1155/2011/621627.
18. Zerkalenkova E.A., Illarionova O.I., Kazakova A.N. et al. Change in linear differentiation in the recurrence of acute leukemia with the rearrangement of the MLL gene (KMT2A). Literature review and case description. Onkogematologiya, 2016, vol. 11, no. 2, pp. 21-28 (in Russ.).