E.E. IOYLEVA¹, M.S. KRIVOSHEEVA²

¹S. Fyodorov Eye Microsurgery Federal State Institution, 59а Beskudnikovsky Blvd, Moscow, Russian Federation, 127486

²Sergiev Posad District Hospital, 62a Novouglichskoye shosse, Sergiev Posad, Russian Federation, 141301

 Ioyleva E.E. ― D. Sc. (medicine), scientific secretary, Professor of the Department of Ophthalmology of Moscow State University for Medicine and Dentistry named after A.I. Evdokimov, tel. (499) 488-85-24, e-mail: nauka@mntk.ru

Krivosheeva M.S. ― ophthalmologist of the Surgical Department, e-mail: krivosheeva_ms@mail.ru

The article deals with the aspects of diagnostic significance of the complex of retinal ganglion cells and the inner plexiform layer in patients with optic neuritis in the manifestation of multiple sclerosis using spectral optical coherence tomography. The research showed a reduction in the thickness of the complex of retinal ganglion cells and the inner plexiform layer to 76.23 μm in the group with optic neuritis due to MS compared with normal indices (82 μm). This indicator can be regarded as a marker of early diagnosis of multiple sclerosis. Thus, revealing a decrease in the thickness of ganglion cells of the retina may indicate the demyelinating nature of ON under further development of optic atrophy during the disease manifestation.

Key words: optic neuritis, multiple sclerosis, spectral optical coherence tomography, retinal ganglion cell complex and inner plexiform layer

(For citation: Ioyleva E.E., Krivosheeva M.S. Significance of assessment of neuroarchitectonics of the retina under optic neuritis. Practical Medicine. 2018)

REFERENCES

1. Kovalenko A.B., Boyko E.V., Odinnak M.M. et al. Diagnostic possibilities of optical coherence tomography in patients with multiple sclerosis. Vestn. Ros. Voen.-med. akad., 2009, no. 4 (28), pp. 16-21 (in Russ.).
2. Ioyleva E.E. Differential diagnosis of optic neuritis and anterior ischemic neuropathy. Oftal’mokhirurgiya, 2002, no. 2, pp. 31-34 (in Russ.).
3. Ioyleva E.E., Krivosheeva M.S., Smirnova M.A. Results of examination of patients with optic neuritis in the onset of multiple sclerosis. Vestnik OGU, 2014, no. 12, pp. 143-146 (in Russ.).
4. Krivosheeva M.S. Rezul’taty obsledovaniya patsientov s opticheskim nevritom i atrofiey zritel’nogo nerva vsledstvie rasseyannogo skleroza metodami opticheskoy kogerentnoy tomografii i mikroperimetrii: avtoref. dis. … kand. med. nauk [Results of examination of patients with optic neuritis and optic atrophy due to multiple sclerosis using optical coherence tomography and microperimetry. Synopsis of dis. PhD med. sci]. Moscow, 2018. 29 p.
5. Brandt A.U., Oberwahrenbrock T., Ringelstein M., et al. Primary retinal pathology in multiple sclerosis as detected by optic coherence tomography (letter to the editor). Brain, 2011, vol. 134, pp. 1-3.
6. Kupersmith M.J., Kardon R., Durbin M.K., Shulman J. Scanning laser polarimetry reveals status of RNFL integrity in eyes with optic nerve head swelling by OCT. Investigation Ophthalmological Visus Science, 2012, vol. 53, pp. 1962-1970.
7. Saidha S., Syc S.B., Ibrahim M.A., et al. Primary retinal pathology in multple sclerosis as detected by optical coherence tomography. Brain, 2011, vol. 134, pp. 518-533.
8. Siger M., Dziegielewski K., Jasek L., et al. Optical coherence tomography in multiple sclerosis. The thickness of the retinal nerve fiber layer as a potential measure of axonal loss and brain atrophy. Neurology, 2008, vol. 255, pp. 1555-1560.
9. Winges K.M., Werner J.S., Harvey D.J., et al. Baseline retinal nerve fiber layer thickness and macular volume quantified by OCT in the North American phase 3 fingolimod trial for relapsing-remitting multiple sclerosis. Neuroophthalmology, 2013, vol. 33, pp. 322-329.
10. Davydovskaya M.V., Tsysar’ M.A., Boyko A.N., Akopyan V.S. et al. Damage of a complex of ganglion cells and a layer of retinal nerve fibers in multiple sclerosis. Zhurnal nevrologii i psikhiatrii, 2012, iss. 2, no. 2, pp. 47-51 (in Russ.).
11. Oberwahrenbrock T., Ringelstein M., Jentschke S., et al. Retinal ganglion cell and inner plexiform layer thinning in clinically isolated syndrome. Multiple Sclerosis Journal, 2013, vol. 19, pp. 1887-1895.
12. Ratchford J.N., Saidha S., Sotirchos E.S., et al. Active MS is associated with accelerated retinal ganglion cell/inner plexiform layer thinning. Neurology, 2013, vol. 80, pp. 47-54.
13. Syc S.B, Saidha S., Newsome S.D., et al. Optical coherence tomography segmentation reveals ganglion cell layer pathology after optic neuritis. Brain, 2012, vol. 135, pp. 521-533.
14. Gusev E.I., Zavalishin I.A., Boyko A.N. Rasseyannyy skleroz, klinicheskoe rukovodstvo [Multiple sclerosis, clinical guidelines]. Moscow, 2011. 782 p.
15. Avetisov S.E. et al. Oftal’mologiya. Natsional’noe rukovodstvo [Ophthalmology. National leadership]. Moscow: GEOTAR-Media, 2011. 944 p.
16. Zelentsov S.N., Zelentsova V.M. Rol’ opticheskoy kogerentnoy tomografii v diagnostike rasseyannogo skleroza [The role of optical coherence tomography in the diagnosis of multiple sclerosis]. Aktual’nye voprosy neyrooftal’mologii: sb. nauch. st. Moscow, 2011. Pp. 13-14.
17. Ioyleva E.E., Gadzhieva N.S., Krivosheeva M.S., Kuteynikova M.E. Sposob ranney diagnostiki retrobul’barnogo nevrita pri debyute rasseyannogo skleroza no. 2548511 ot 29.11.2013 [The method of early diagnosis of retrobulbar neuritis in the debut of multiple sclerosis № 2548511 from 11/29/2013].
18. Kovalenko A.B. Early diagnosis of visual disturbances in multiple sclerosis. Pyatiminutka, 2010, no. 1 (10), pp. 64-68 (in Russ.).
19. Maslova N.N., Andreeva E.A. Possibilities of neuro-ophthalmologic examination in early diagnosis of multiple sclerosis. Meditsinskiy al’manakh, 2013, vol. 29, no. 5, pp. 201-203 (in Russ.).
20. Balcer L.J., Miller D.H., Reingold S.C., Cohen J. A Vision and vision-related outcome measures in multiple sclerosis. Brain, 2015, Jan, 138 (1), pp. 11-27.
21. Optic Neuritis Study Group. Visual function 15 years after optic neuritis: a final follow-up report from the Optic Neuritis Treatment Trial. Opththalmology, 2008b, vol. 115, pp. 1079-1082.
22. Akopyan V.S., Boyko A.N., Davydovskaya M.V., Semenova N.S. et al. Neuroarchitectonics of the retina in multiple sclerosis: diagnostic capabilities of optical coherence tomography (preliminary results). Oftal’mologiya, 2011, no. 1, pp. 32-36 (in Russ.).
23. Davies E.C., Galetta K.M., Sackel D.J., et al. Retinal ganglion cell layer volumetric assessment by spectral-domain optical coherence tomography in multiple sclerosis: application of a high-precision manual estimation technique. Journal Neuroophthalmology, 2011, vol. 31, pp. 260-264.
24. Toosy A.T., Mason D.F., Miller D.H. Optic neuritis. Lancet Neurology, 2014, vol. 13, pp. 83-99.