S.V. MALTSEV¹, L.Z. SAFINA²

 ¹Russian Medical Academy of Continuous Professional Education MOH Russia, Moscow

²Kazan State Medical Academy — Branch Campus of the FSBEI FPE RMACPE MOH Russia, Kazan

Contact:

Maltsev S.V. – Honored Researcher of the Russian Federation and Republic of Tatarstan, corresponding member of the Academy of Sciences of the Republic of Tatarstan, MD, Professor of the Department of Pediatrics named after Prof. G.N. Speranskiy

Address: 2/1 Barrikadnaya Str., building 1, 123242, Moscow, Russian Federation, tel. +7-905-314-40-28, e-mail: [email protected]

 Scientific studies of the last decade on the composition and function of the human intestine microflora have caused a new wave of interest in studying the relationship between microbiota disorders and the development of inflammatory etiology diseases. The present review summarizes the literature on the effect of the intestinal microbiome on the mechanisms of vaccine-induced immunity formation. A series of studies using the latest technologies and analytical methods are described, which showed that the intestinal microbiota activates many pathways that control innate and adaptive immunity in the intestine. The review provides evidence that the use of probiotics in specific courses before and after vaccination (in particular with oral vaccines) can improve seroconversion rates in children. The prospects of using the immunomodulating potential of probiotic strains as a means of increasing the efficiency of vaccination are highlighted.

Key words: antigenic stimulation, intestinal microbiota, vaccination, immunomodulation, probiotic functions.

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