E.N. IVANTSOV, N.R. KHASANOV, M.A. MAKAROV

 Kazan State Medical University, Kazan

 Contact details:

Ivantsov E.N. — PhD (medicine), Assistant Lecturer of the Department of Propaedeutics of Internal Diseases named after Prof. S.S. Zimnitskiy

Address: 49 Butlerov St., Kazan, Russian Federation, 420012, tel.: +7-958-620-44-86, e-mail: evgeniy.ivancov@kazangmu.ru

Diabetes mellitus is widespread in developed countries and plays an important role in the pathogenesis of coronary artery atherosclerosis leading to coronary heart disease. There are many markers of genetic polymorphism that determine the predisposition to type 2 diabetes mellitus, and their list is growing.

The purpose of the study was to research the effect of genetic factors characteristic for patients with acute coronary syndrome with and without diabetes mellitus on the severity of coronary artery disease among polymorphic variants of the rs699947 VEGF-A gene, rs9349379 of the PHACTR1 gene, rs3825807 of the ADAMTS7 gene, rs2891168 of the CDKN2B gene, rs3184504 of the gene SH2B3, and rs1746048 of the CXCL12 gene.

Material and methods. The study included 238 patients hospitalized in the Cardiology Department of Municipal Clinical Hospital No. 7 of Kazan with acute coronary syndrome (mean age was 62.6±11.1 years), including 158 (66.4%) men and 80 (33.6%) women. In 44 (18.5%) patients with diabetes mellitus, on average, the Gensini scale value was 12 points higher, which characterizes a more severe coronary artery disease; they also had a higher frequency of occurrence of the AA rs699947 genotype of the VEGF gene (OR 2.8; 95 % CI: 1.415–5.711) and CT genotype rs3825807 of the ADAMTS7 gene (OR 2.5; 95% CI: 1.207–4.622). However, the analysis of polymorphic variants rs699947 of the VEGF gene and rs3825807 of the ADAMTS7 gene in patients with acute coronary syndrome associated with diabetes mellitus in a linear regression model did not reveal their significant effect on the severity of coronary artery lesions assessed by the Gensini scale.

Key words: diabetes mellitus, atherosclerosis, acute coronary syndrome, rs699947 of the VEGF gene, rs3825807 of the ADAMTS7 gene.

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