A.E. KHRULEV¹, V.N. GRIGORYEVA¹, E.N. SOLOVYANOVA¹, N.Yu. LINEVA²

¹Nizhny Novgorod State Medical Academy, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, Russian Federation, 603005

²Nizhny Novgorod Regional Clinical Hospital, 190 Rodionov Str., Nizhny Novgorod, Russian Federation, 603126 

Khrulev A. E. — Cand. Med. Sc., Associate Professor of the Department of Neurology, Neurosurgery and Medical Genetics, tel. (831) 438-95-67, e-mail: alexey_khrulev@mail.ru

Grigoryeva V.N. — D. Med. Sc., Professor, Head of the Department of Neurology, Neurosurgery and Medical Genetics, tel. (831) 438-90-01, e-mail: vrgr@yandex.ru

Solovyanova E.N. — Cand. Med. Sc., Associate Professor of the Department of Internal Diseases named after V.G. Vogralik, tel. (831) 438-91-36, e-mail: elenas-nn@mail.ru

Lineva N.Yu. — Head of the Department of Dialysis and Gravitational Surgery of Blood, tel. (831) 438-93-49, e-mail: lineva_natalja@rambler.ru

 Cerebral vascular disorders in patients with chronic kidney disease (CKD) are discussed in the article. The main pathogenic mechanisms of damage to cerebral vessels in patients with CKD are described. The main risk factors of cerebral vascular disorders, as well as strategies of their correction in patients with CKD are discussed in detail. Attention is drawn to the need for early diagnosis and timely correction of glomerular filtration rate and albuminuria, arterial hypertension, atherosclerosis and dyslipidemia, vascular calcification, β2-macroglobulinemia and cerebral amyloid angiopathy. The issues of treatment of patients with CKD, based on recent national and international guidelines, are considered.

Key words: chronic kidney disease, risk factors, cerebral vascular disorders, stroke, transient ischemic attack, chronic cerebral ischemia, subarachnoid hemorrhage, treatment.

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