A.V. NIKOLAEVA, L.T. PIMENOV, M.V. DUDAREV, A.V. MELNIKOV

Izhevsk State Medical Academy, 281 Kommunarov Str., Izhevsk, Russian Federation, 426034 

Nikolaeva A.V. ― Cand. Med. Sc., Associate Professor of the Department of Polyclinic Therapy with the courses of Clinical Pharmacology and Preventive Medicine, tel. +7-912-464-18-50, e-mail: allavn@inbox.ru

Pimenov L.T. ― D. Med. Sc., Professor, Head of the Department for General Practitioners and Internal Diseases with the course of Emergency Medicine, tel. +7-912-851-23-30, e-mail: pimenov45@yandex.ru

Dudarev M.V. ― D. Med. Sc., Associate Professor, Head of the Department of Polyclinic Therapy with the courses of Clinical Pharmacology and Preventive Medicine, tel. +7-912-767-28-33, e-mail: flatly@yandex.ru

Melnikov A.V. ― Cand. Med. Sc., Associate Professor of the Department of Polyclinic Therapy with the courses of Clinical Pharmacology and Preventive Medicine, tel. +7-912-851-44-67, e-mail: forma45@mail.ru

 The article shows the results of examination of 187 female patients with primary hypothyroidism depending on the level of thyroid failure. The examination included assessment of clinical, hemodynamic parameters, lipid and hormonal profile, endothelium function and kidney filtration function. It was demonstrated that the examined patients had such risk factors as obesity, arterial hypertension, atherogenic dyslipidemia, endothelium dysfunction, subclinical atherosclerosis, diastolic dysfunction and left ventricle hypertrophy. Disease compensation and long-term levothyroxine therapy did not lead to the decrease of risk factors severity.

Key words: primary hypothyroidism, risk factors, dyslipidemia, endothelium dysfunction.

REFERENCES

1. Grais I.M., Sowers J.R. Thyroid and the heart. Am. J. Med, 2014, 127, pp. 691-698.
2. Singh S., Duggal J., Molnar J. et al. Impact of subclinical thyroid disorders on coronary heart disease, cardiovascular and all-cause mortality: a meta-analysis. Int. J. Cardiol, 2008, 125, pp. 41-48.
3. Somwaru L.L., Rariy C.M., Arnold A.M., Cappola A.R. The natural history of subclinical hypothyroidism in the elderly: the cardiovascular health study. J. Clin. Endocrinol. Metab, 2012, 97, pp. 1962-1969.
4. Nikolaeva A.V., Pimenov L.T. Lipid metabolism and functional state of the kidneys in patients with hypothyroidism depending on the phase of the disease. Terapevticheskiy arkhiv, 2002, vol. 74, no. 10, pp. 20-23 (in Russ.).
5. Renehan A.G. et al. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet, 2008, 371 (9612), pp. 569-578.
6. Paul Leeson, Daniel Augustine, Andrew R.J. Mitchell, and Harald Becher. Echocardiography. Oxford Specialist Handbooks in Cardiology. Second Edition; 2012, pp. 174-178.
7. Kots Ya.I., Denisov E.N., Bakhtiyarov R.Z. Ultrasonic methods of endothelial function research. Terapevticheskiy arkhiv, 2005, vol. 6, pp. 32-34 (in Russ.).
8. Levey A.S., de Jong P.E., Coresh J. et al. The definition, classification and prognosis of chronic kidney disease: a KDIGOC ontroversies Conference report. Kidney Int, 2010, available at: http:/www.kidney‐international.org
9. Sorokin E.V. Cardiovascular diseases, microalbuminuria and statins: is a new breakthrough expected? Russkiy meditsinskiy zhurnal, 2010, no. 22, pp. 1327-1331 (in Russ.).
10. Danlof B., Devereux R.B., Kieldsen S.E., et al, for the LIFE study group. Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet, 2002, 359, pp. 995-1003.