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  • Results of a 12-month follow-up of neovascular age-related macular degeneration after switching an angiogenesis inhibitor in real clinical practice

    Редактор | 2018, Practical medicine 03 (18) Ophthalmology | 10 апреля, 2018

    E.V. BOBYKIN, S.A. KOROTKIKH, R.V. BUSLAEV

    Ural State Medical University, 3 Repin St., Ekaterinburg, Russian Federation, 620028

      Bobykin E.V. ― Cand. Med. Sc., Assistant Professor, Assistant Professor of the Ophthalmology Department, tel. (343) 214-80-00, e-mail: [email protected]

    Korotkikh S.A. ― D. Med. Sc., Professor, Head of the Ophthalmology Department, tel. (343) 214-86-67, e-mail: [email protected]

    Buslaev R.V. ― clinical resident of the Ophthalmology Department, tel. (343) 214-80-00, e-mail: [email protected]

    The 12-month monitoring after «switching» from ranibizumab to aflibercept in the study group (n=21) revealed a statistically significant improvement in the anatomic parameters of the macula (a decrease in the central thickness of the retina from 325.3±20.2 to 263.2±17.1 μm {p<0,05} and the volume of the macula from 7.77±0.28 to 6.93±0.24 mm3 (p<0.05}), as well as a tendency to increase the best corrected visual acuity (from 0.39±0.05 to 0.43±0.05, p> 0.05). In 7 (33.3%) cases, the tactic of returning to the original drug («switch back») was applied for various reasons. The change in therapy as a single intravitreal injection performed during recurrences of the disease activity, did not contribute to a significant change in the number of injections (decrease from 3.19±0.22 to 2.81±0.34, p> 0.05) and adherence of patients to treatment (an increase in the proportion of patients with low compliance from 43.8 to 50.0% of patients; p>0.05) as compared with the 12 months preceding the study.

    Key words: neovascular («wet») age-related macular degeneration, ranibizumab, aflibercept switching, switch back.

    REFERENCES

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    Метки: 2018, aflibercept switching, E.V. BOBYKIN, neovascular («wet») age-related macular degeneration, Practical medicine 03 (18) Ophthalmology, R.V. BUSLAEV, ranibizumab, S.A. KOROTKIKH, switch back

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