E.I. KAIRBEKOVA¹, N.A. TOTOLYAN²,G.S. MAKSHAKOV²,A.A. SKOROMETS^1,2, E.P.EVDOSHENKO^1,2

¹City Clinical Hospital № 31, Saint-Petersburg Municipal Center for Multiple Sclerosis and other Autoimmune Diseases, 3 Prospekt Dinamo, Saint Petersburg, Russian Federation, 197110

²First Saint-Petersburg State Medical University named after I.P. Pavlov, 6-8 Lev Tolstoy St., Saint-Petersburg, Russian Federation, 197022 

Kairbekova E.I. — neurologist, tel.: +7-981-680-29-30, e-mail: [email protected]¹

Totolyan N.A. — D. Med. Sc., Professor of the Department of Neurology and Neurosurgery, tel.: (812) 234-16-25, e-mail: [email protected]²

Makshakov G.S. — intern doctor of the Department of Neurology and Neurosurgery, tel.: +7-921-391-21-01, e-mail: [email protected]²

Skoromets A.A. — Academician of the Russian Academy of Medical Science, Honored Researcher of the Russian Federation, D. Med. Sc., Professor, Head of the Department of Neurology and Neurosurgery, Chief Neurologist of Saint-Petersburg, tel.: (812) 234-16-25, e-mail: [email protected]^1,2

Evdoshenko E.P.— PhD (Medicine), Director of Saint-Petersburg Center for Multiple Sclerosis and other Autoimmune Diseases, City Clinical Hospital № 31, Assistant of the Department of Neurology and Neurosurgery, tel. +7-911-740-23-89, e-mail: [email protected]^1,2

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system related to the processes of demyelination and neurodegeneration. Recent studies report that 43-65 % of patients with MS have cognitive impairment. The aim of the study was to assess the relationship of cognitive disorders with brain atrophy with the help of magnetic resonance imaging (MRI). The atrophy degree was assessed by brain MRI results with the further calculation of internuclear index. Thus, we have examined 25 patients with MS and low levels of disability (EDSS <4.0) and 25 healthy controls using a battery of neuropsychological testsandMRI-evaluated internuclear index. Although cognitive disprders were revealed in 40% of MS patients, there was poor relationship reported between MRI-internuclear index abnormalities and the degree of cognitive disorder.

Key words: multiple sclerosis, cognitive disorder, magnetic resonance imaging, internuclear index.

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