O.V. SHURYGINA, A.N. ULANOV, O.V. KULAKOVA, Yu.V. GRIGORJEVA

 Samara State Medical University of the Ministry of Health of the Russian Federation

 Contact details:

Shurygina O.V. – D.Sc. (medicine), Professor, Associate Professor of the Department of Histology and Embryology

Address: 89 Chapaevskaya St., Samara, Russian Federation, 443001, tel. (846) 333-36-84

The aim of the work is a complex histological analysis of morphological manifestations of reparative regeneration of smooth muscle tissue of the vaginal wall.

Material and methods. To identify the features of the mechanisms of reparative regeneration, two series of experiments were carried out: metered stretching and dissection of the tissues of the vaginal wall. With the help of a complex of histological techniques, the features of cellular and intracellular regeneration of muscle tissue were studied.

Results.  Depending on the method of damage to the tissues of the vaginal wall, the replacement ability of the connective tissue of the organs differs. In the simulation of experimental stretching, this ability is less pronounced, which is most likely due to the wide range of variability of smooth muscle tissue, which is determined and fixed during the evolutionary processes of vaginal organogenesis, since the stretching of the organ during labor is regular. When dissection becomes more active the substitutionary role of the connective tissue, their own potencies of leiomyocytuses with this method of damage is not enough.

Conclusion. The degree of replacement regeneration of the muscle tissue of the vaginal wall due to the connective tissue is determined by the quality of the disturbing factor. A unique feature was revealed for the definitive muscle tissue — change of cell phenotypes and compensatory manifestation of the synthetic activity of smooth myocytes.

 Key words: vagina, cervix of uterus, smooth muscle tissue, regeneration.