V.M. KHOKKANEN¹, A.V. KARETSKIY², E.V. LOPATINA^3,4

¹North-Western State Medical University named after I.I. Mechnikov, 1/82 Zanevskiy Ave., Saint Petersburg, Russian Federation, 195196

²Saint Petersburg Scientific and Research Institute, 13-2 2^nd Murinskiy Ave., Saint Petersburg, Russian Federation, 194064

³Institute of Physiology of the Russian Academy of Sciences named after I.P. Pavlov, 6 Quay of Makarov, Saint Petersburg, Russian Federation, 199034

⁴North-Western State Medical Federal Centre named after V.A. Almazov, 2 Akkuratov St., Saint Petersburg, Russian Federation, 197341 

Khokkanen V.M. ― D. Med. Sc., Professor of the Department of Ophthalmology, tel. (812) 303-50-00, (2232), e-mail: Valentina.Khokkanen@szgmu.ru

Karetskiy A.V. ― Cand. Med. Sc., Head of the Department of Phtisioophthalmology, tel. (812) 552-09-40, e-mail: Glazniif@mail.ru

Lopatina E.V. ― D. Biol. Sc., Leading researcher of the Division of experimental Physiology and Pharmacology, Laboratory of excitable membranes, tel. (812) 702-37-30, е-mail: fmrc@almazovcent.rus

The article presents the results of an experimental study of the drug Anoceptin action in organotypic culture of chick embryo retina and in a model of tuberculous chorioretinitis in rabbits. The positive role of Anoceptin in saving retinal pigment epithelial cells is proved even in case of such destructive disease as ocular tuberculosis. Taking into account the fact that damage of retinal pigment epithelium is one of the main pathogenic causes of retinal and choroidal degenerative diseases, the application of Anoceptin may prevent their occurrence.

Key words: retinal pigment epithelium, secondary dystrophy, complications of chorioretinitis, ocular tuberculosis, Anoceptin, comenic acid.