E.M. SPERANSKAYA^1,3, L.R. MUKHAMEDZHANOVA^1,2, N.N. GOLUBTSOVA¹, R.G. KUZNETSOVA⁴

¹Chuvash State University named after I.N. Ulyanov, 15 Moskovskiy Pr., Cheboksary, Russian Federation, 428015

²Training and methodological center «Eksklyuziv-dent», 42 Kosmonavtov Str., Kazan, Russian Federation, 420061

³Republican Dental Clinic of the Ministry of Health of the Chuvash Republic, 15 Moskovskiy Pr., Cheboksary, Russian Federation, 428015

⁴Republican Clinical Hospital of the MH of RT, 138 Orenburgskiy Trakt, Kazan, Russian Federation, 420064

Speranskaya E.M. ― resident physician of the Department of propaedeutics of dental diseases and new technologies, tel. +7-917-662-93-53, e-mail: [email protected]

Mukhamedzhanova L.R. ― D. Med. Sc., Professor of the Department of propaedeutics of dental diseases and new technologies, scientific consultant of the Training and methodological center «Eksklyuziv-dent», tel. +7-965-597-11-64, e-mail: [email protected]

Golubtsova N.N. ― Cand. Biol. Sc., Professor of the Department of general and clinical morphology and forensic medicine, tel. +7-905-340-77-99, e-mail: [email protected]

Kuznetsova R.G. ― senior researcher of the Scientific and Research Department, tel. (843) 231-16-20, e-mail: [email protected] 

In this article is studied the content of the marker Ki-67, the activity of the exfoliative processes, the number of degranulated mast cells in the connective tissue structures of the periodontium of patients burdened with chronic generalized periodontitis. Also, has been established the oppression of proliferation processes in the structures of the stratified squamous epithelium of the gums, the increase in the content of degranulated mast cells, the reinforcement of the exfoliation processes in the keratinized epithelium in the patients of the study group. The findings make actual search of methods of proliferative processes regulation in the epithelium of the gingiva.

Key words: chronic generalized periodontitis, a marker of proliferation Ki-67, mast cells, exfoliation of epithelial cells.

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