E.M. SPERANSKAYA^1,3, L.R. MUKHAMEDZHANOVA^1,2, N.N. GOLUBTSOVA¹, R.G. KUZNETSOVA⁴

¹Chuvash State University named after I.N. Ulyanov, 15 Moskovskiy Pr., Cheboksary, Russian Federation, 428015

²Training and methodological center «Eksklyuziv-dent», 42 Kosmonavtov Str., Kazan, Russian Federation, 420061

³Republican Dental Clinic of the Ministry of Health of the Chuvash Republic, 15 Moskovskiy Pr., Cheboksary, Russian Federation, 428015

⁴Republican Clinical Hospital of the MH of RT, 138 Orenburgskiy Trakt, Kazan, Russian Federation, 420064

Speranskaya E.M. ― resident physician of the Department of propaedeutics of dental diseases and new technologies, tel. +7-917-662-93-53, e-mail: [email protected]

Mukhamedzhanova L.R. ― D. Med. Sc., Professor of the Department of propaedeutics of dental diseases and new technologies, scientific consultant of the Training and methodological center «Eksklyuziv-dent», tel. +7-965-597-11-64, e-mail: [email protected]

Golubtsova N.N. ― Cand. Biol. Sc., Professor of the Department of general and clinical morphology and forensic medicine, tel. +7-905-340-77-99, e-mail: [email protected]

Kuznetsova R.G. ― senior researcher of the Scientific and Research Department, tel. (843) 231-16-20, e-mail: [email protected] 

In this article is studied the content of the marker Ki-67, the activity of the exfoliative processes, the number of degranulated mast cells in the connective tissue structures of the periodontium of patients burdened with chronic generalized periodontitis. Also, has been established the oppression of proliferation processes in the structures of the stratified squamous epithelium of the gums, the increase in the content of degranulated mast cells, the reinforcement of the exfoliation processes in the keratinized epithelium in the patients of the study group. The findings make actual search of methods of proliferative processes regulation in the epithelium of the gingiva.

Key words: chronic generalized periodontitis, a marker of proliferation Ki-67, mast cells, exfoliation of epithelial cells.

 

 

REFERENCES

1. Grudyanov A.I., Dmitrieva L.A., Maksimovskiy Yu.M. Periodontics. The current state of the question and the direction of scientific research. Stomatologiya, 1999, no. 1, pp. 16-21 (in Russ.).
2. Maksimovskiy Yu.M., Mitronin A.V. The main directions of the prevention and treatment of chronic inflammation in periodontal. Rossiyskiy stomatologicheskiy zhurnal, 2004, no. 1, pp. 16-19 (in Russ.).
3. Kaner D., Bemimoulin J.P., Kleber V.M., Friedmann A. Minimally invasive flap surgery and enamel matrix derivative in the treatment of localized aggressive periodontitis: case report. Int. J. Periodontics Restorative Dent, 2009, no. 29 (1), pp. 89-97.
4. Osipova Yu.L., Bulkina N.V., Kropotina A.Yu. Inflammatory periodontal disease with erosive form of gastroesophageal reflux disease: clinical and immunomorfological aspects. Fundamental’nye issledovaniya, 2012, no. 2-2, pp. 325-327 (in Russ.).
5. Artashyan O.S. Sistema tuchnykh kletok pri deystvii na organizm ekstremal’nykh faktorov: avtoref. dis. … kand. biol. nauk [Mast cell system at action on an organism of extreme factors. Synopsis of dis. PhD biol. sciences], 2006. 28 p.
6. Grigorovich E.Sh., Gorodilov R.V., Zablotskaya E.A. Cellular gingival epithelium update in patients with chronic generalized periodontitis under the influence of the initial periodontal therapy. Institut stomatologii, 2011, no. 2 (51), pp. 62-65 (in Russ.).
7. Klimin V.G. Mast cells and hypoxia. Vestnik Ural’skoy meditsinskoy akademicheskoy nauki, 2006, no. 1, pp. 45-48 (in Russ.).
8. Kondrashevskaya M.V. Mast cells and heparin — a key element in the adaptive and pathological processes. Vestnik Rossiyskoy akademii meditsinskikh nauk, 2010, no. 6, pp. 49-54 (in Russ.).
9. Yaglova N.V., Yaglov V.V. Biology secretion of mast cells. Klinicheskaya i eksperimental’naya morfologiya,2012, no. 4, pp. 4-10 (in Russ.).
10. Kamyshnikov V.S. Onkomarkery: metody opredeleniya, referentnye znacheniya, interpretatsiya testov [Tumor markers: the methods of determining reference values, the interpretation of tests]. Moscow: MEDpress-inform, 2001. 128 p.
11. Osipova Yu.L., Bulkina N.V., Kropotina A.Yu. et al. The role of mast cells of the mucous membrane gums in the pathogenesis of inflammatory periodontal diseases. Fundamental’nye issledovaniya, 2009, no. 7, p. 55 (in Russ.).
12. Amin K. The role of mast cells in allergic inflammation. Respir. Med, 2012, vol. 106, pp. 9-14.
13. Preethi P.L., Rao S.R., Madapusi B.T., Narasimhan M. Immunolocalization of Ki-67 in different periodontal conditions. J. Indian Soc. Periodontol, 2014, Mar, 18 (2), P. 161-5.
14. Osipova Yu.L. Vospalitel’nye zabolevaniya parodonta pri gastroezofageal’noy reflyuksnoy bolezni: prognozirovanie techeniya i taktika vedeniya: dis. … dok. med. nauk [Inflammatory periodontal disease with gastroesophageal reflux disease. Dis. Dr med. sciences], 2015. 260 p.
15. Shatskikh O.A. Morfologicheskaya kharakteristika timusa v usloviyakh postupleniya melatonina [Morphological characteristics of the thymus in a melatonin revenue], 2015, 172 p.
16. Gunin A.G., Petrov V.V., Golubtzova N.N. et al. Age-related changes in angiogenesis in human dermis. Exp. Gerontol, 2014, vol. 55, pp. 143-151.