E.M. SPERANSKAYA^1,3, L.R. MUKHAMEDZHANOVA^1,2, N.N. GOLUBTSOVA¹, R.G. KUZNETSOVA⁴

¹Chuvash State University named after I.N. Ulyanov, 15 Moskovskiy Pr., Cheboksary, Russian Federation, 428015

²Training and methodological center «Eksklyuziv-Dent», 42 Kosmonavtov Str., Kazan, Russian Federation, 420061

³Republic Dental Polyclinic, 15 Moskovskiy Pr., Cheboksary, Russian Federation, 428015

⁴Republic Clinical Hospital of the MH of RT, 138 Orenburgskiy Trakt, Kazan, Russian Federation, 420064

 Speranskaya E.M. ― resident doctor of the Department of Propaedeutics of Stomatologic Diseases and New Technologies, tel. +7-917-662-93-53, e-mail: [email protected]

Mukhamedzhanova L.R. ― D. Med. Sc., Professor of the Department of Propedeutics of Stomatology Diseases and New Technologies, tel. +7-965-597-11-64, e-mail: [email protected]

Golubtsova N.N. ― Cand. Biol. Sc., Associate Professor of the Department of General and Clinical Morphology and Forensic Medicine, tel. +7-905-340-77-99, e-mail: [email protected]

Kuznetsova R.G. ― Senior Researcher of the Research Department, tel. (843) 231-16-20, e-mail: [email protected]

 The levels of cellular adhesion marker E-cadherin and proliferation marker p-53 were studied in the structures of multilayered flat keratinized epithelium of the gums of patients with chronic generalized periodontitis. Inhibition of cell adhesion and increase of proliferation in the structures of multilayered flat epithelium of the gum was found, as well as the increase in the parameters (number, height, width) of connective tissue papillae of multilayered flat epithelium. The obtained results actualize the search for regulation methods of the proliferation and adhesion processes in the gingival epitheliocytes.

Key words: chronic generalized periodontitis, antiapoptotic protein p-53, marker of cell adhesion E-cadherin.

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