T.V. NIKISHOVA¹, A.A.YAKUPOVA², R.A. YAKUPOV³, I.F. SHAFIKOV³, M.N. GRISHKINA¹

 ¹Kazan State Medical Academy — Branch Campus of the FSBEI FPE RMACPE MOH Russia, Kazan

²Kazan State Medical University, Kazan

³ RAKHAT Clinic of Innovative Medicine, Kazan

 Contact details:

Nikishova T.V. — PhD (medicine), Associate Professor of the Department of Endocrinology

Address: 36 Butlerov St., Kazan, Russian Federation, 420012, tel.: +7-903-340-28-67, e-mail: ntv116@mail.ru

The purpose — to develop a method for preventive differentiated therapy of exogenous-constitutional obesity recurrence in females based on monitoring of psychophysiological reactivity and neurohumoral regulation.

Material and methods. 241 females with exogenous-constitutional obesity and 45 healthy females were examined. The patients of the main (123 persons) and control (118 persons) groups were under observation during 8 months. The body mass index, the leptin hormone level, and the duration of blink reflex were assessed on monitoring. Reflexotherapy, diet therapy and physiotherapy were applied in the main group. Statistical processing was performed by nonparametric methods.

Results. Variants of developing obesity recurrence were determined: 1) with primary change of psychophysiological reactivity; 2) with primary change of neurohumoral regulation. In the first variant, reflexotherapy was prescribed, and in the second — hypocaloric diet and physiotherapy.

The obesity recurrence in the control group was registered in 85.6% of all observations, and in the main group — in 14.6% of observations (p < 0.01).

Conclusions. The proposed method of preventive differentiated therapy based on monitoring of psychophysiological reactivity and neurohumoral regulation allowed decreasing the recurrence rate in females with exogenous-constitutional obesity.

Key words: exogenous-constitutional obesity, blink reflex, leptin, prevention of obesity recurrence.

REFERENCES

1. Patel K. Obesity treatment: a focus on pharmacotherapy of weight management. Orthop Nurs, 2020, vol. 39 (2), pp. 121–127. DOI: 10.1097/NOR.0000000000000643
2. Drapkina O.M., Samorodskaya I.V., Starinskaya M.A., Kim O.T, Neymark A.E. Ozhirenie: otsenka i taktika vedeniya patsientov [Obesity: evaluation and management of patients]. Moscow: OOO “Silitseya-Poligraf”, 2021. 174 p.
3. Savel’eva L.V. Modern concept of obesity treatment. Ozhirenie i metabolizm, 2011, no. 8 (1), pp. 51–56 (in Russ.).
4. Kuz’mina-Krutetskaya S.R., Repina M.A. Metabolicheskiy sindrom u zhenshchin. 2-e izd., pererab. i dop. [Metabolic syndrome in women. 2nd ed., revised. and additional]. Saint Petersburg: OOO “Eko-Vektor”, 2019. 72 p.
5. Pinkhasov B.B. Pathogenetic features of primary obesity and its types in women of reproductive age. MEZh, 2011, no. 8 (40) (in Russ.).
6. Liu J., Yang X., Yu S., Zheng R. The Leptin Resistance.Adv Exp Med Biol, 2018, vol. 1090, pp. 145–163. DOI: 10.1007/978-981-13-1286-1_8
7. Butrova S.A. Terapiya ozhireniya. Ozhirenie: etologiya, patogenez, klinicheskie aspekty [Therapy for obesity. Obesity: ethology, pathogenesis, clinical aspects]. Moscow: Meditsinskoe informatsionnoe agentstvo, 2004. Pp. 378–405.
8. Nikolaev S.G. Praktikum po klinicheskoy elektromiografii. Izd. 2-e, dop. [Workshop on clinical electromyography. Ed. 2nd, add.]. Ivanovo: Ivan. gos. med. akademiya, 2003. 264 p.
9. Ametov A.S., Doskina E.V., Stel’makh M.V. Influence of weight loss on erectile dysfunction and quality of life in men with obesity. Mediko-sotsial’naya ekspertiza i reabilitatsiya, 2014, no. 4, pp. 49–52 (in Russ.).
10. Tsyganenko O.I., Persheguba Ya.V., Paladina O.L., Sklyarova N.A., Oksamytnaya L.F. The problem of inadequate (deviant) eating behavior of persons engaged in fitness and during physical rehabilitation as a component of health-improving fitness programs, ways to solve it. Fizicheskoe vospitanie studentov, 2013, no. 2, pp. 63–68 (in Russ.).
11. Razina A.O., Runenko S.D., Achkasov E.E. The role of physical rehabilitation in the complex treatment of obesity and correction of overweight. Vestnik Vserossiyskogo obshchestva spetsialistov po mediko-sotsial’noy ekspertize, reabilitatsii i reabilitatsionnoy industrii, 2015, no. 4, pp. 93–103 (in Russ.).
12. Samosyuk I.Z., Lysenyuk V.P. Akupunktura [Acupuncture]. Moscow: AST-Press, 2004. 528 p.
13. Diet, nutrition and the prevention of chronic diseases: report of a Joint WHO/FAO Expert Consultation. WHO Technical Report Series, No. 916. Geneva: World Health Organization, 2003.
14. Korolev G.I. Classification of means, methods and loads in walking. Vestnik sportivnoy nauki, 2007, no. 4, pp. 2–6 (in Russ.).
15. Kiseleva E.Yu., Strel’nikova I.V. nfluence of aqua aerobics on indicators of subjective and objective health of women. Vestnik sportivnoy nauki, 2007, no. 3, pp. 55–58 (in Russ.).
16. Medik V.A., Tokmachev M.S., Fishman B.B. Statistika v meditsine i biologii. Rukovodstvo v 2-kh tomakh [Statistics in medicine and biology. Guide in 2 volumes]. Moscow: Meditsina, 2000. 764 p.