E.A. MOROZOVA¹, R.R. SERGEEVA², D.V. MOROZOV¹

¹Kazan State Medical Academy — Branch Campus of  RMACPE MH Russia, Kazan

²Children’s City Hospital № 8, Kazan

Contact details:

Morozova E.A. — M.D., professor of the Department of Pediatric Neurology

Address: 36 Butlerov St., Kazan, Russian Federation, 420012, е-mail: [email protected]

 The purpose — to study the clinical and neurophysiological predictors of the formation of neonatal seizures in children with perinatal brain pathology.

Material and methods. During the study, 65 children were divided into two groups. The main study group included 35 children with perinatal brain pathology and neonatal seizures; the second group of children consisted of 30 children with perinatal brain pathology and absence of neonatal seizures. The age of children, at the time of inclusion in the group, ranged from 2 weeks to 18 months. The follow-up of the described patient groups was 3 years. During the study, the patients underwent studies: brain MRI, video-EEG monitoring with the inclusion of a sleep episode, ultrasound of intracranial and extracranial vessels, radiography of the cervical spine, ophthalmoscopy.

Results. As a result of the study, characteristic prenatal, intranatal and instrumental predictors of the formation of neonatal seizures in children with perinatal brain pathology were identified.

Conclusion. Neonatal seizures are a significant pathological state which seriously influence prognosis of children with perinatal brain pathology. Timely assessment of neonatal seizures development risk will improve the list of diagnostic procedures and treatment intervention in cohort of children with perinatal brain pathology.

Key words: neonatal seizures, newborn infants, epilepsy, perinatal brain pathology.

 (For citation: Morozova E.A., Sergeeva R.R., Morozov D.V. Predictors of neonatal seizures development in children with perinatal brain pathology. Practical Medicine. 2019. Vol. 17, № 7, P. 117-120)

REFERENCES

1. Volpe J.J. Neonatal seizures. In: Volpe J.J. Neurology of the newborn, 5th ed. Philadelphia: Elsevier, 2008. Pp. 203–204.
2. Mizrahi E.M. Neonatal seizures. In: Pellock J.M., Bourgeois B.F., Dodson W.E. Pediatric Epilepsy diagnosis and therapy, 3rd ed. New York: Demos, 2008. Pp. 229–240.
3. Lanska M., Lanska D.J., Baumann R.J. et al. A population-based study of neonatal seizures in Fayette County, Kentucky. Neurology, 1995, vol. 45, pp. 724–732.
4. Al_Zwaini E.J., Al_Ani M.M., Mengal A.H. The epidemiology of clinical neonatal seizures in Ramadi city. Neurosciences, 2007, vol. 12, pp. 170–172.
5. Van Rooij L.G.M., van den Broek M.P.H., Rademaker C.M.A., de Vries L.S. Clinical management of seizures in newborns. Pediatr Drugs, 2013, vol. 15, pp. 9–18.
6. Agarwal R.K., Cross H., Elia M., Guerrini R., Hartmann H., Jovic N. et al. Guidelines on neonatal seizures. Geneva: World Health Organization,
7. Mosley M. Neonatal seizures. Pediatr Rev, 2010, vol. 31, pp. 127–128.
8. Volpe J.J. Neonatal seizures. Neurology of the newborn, 5th ed. Philadelphia: Elsevier, 2008. Pp. 203–204.
9. Da Silva L.F.G., Nunes M.L., Da Costa J.C. Risk factors for developing epiliepsy after neonatal seizures. Pediatr Neurol, 2004, vol. 30, pp. 271–277.