Ya.R. NARTSISSOV, E.V. MASHKOVTSEVA, V.S. KOPYLOVA, S.E. BORONOVSKIY

Scientific-Research Institute for Cytochemistry and Molecular Pharmacology, 24 6^th Radial’naya Str., building 14, Moscow, Russian Federation, 115404

Nartsissov Ya.R. — Cand. Phys.-Math. Sc., Associate Professor, Head of Section, tel. (495) 327-49-87, e-mail: [email protected]

Mashkovtseva E.V. — Cand. Phys.-Math. Sc., Senior Researcher, tel. (495) 327-49-87

Kopylova V.S. — Junior Researcher, tel. (495) 327-49-87

Boronovskiy S.E. — Cand. Phys.-Math. Sc., Senior Researcher, tel. (495) 327-49-87

Depression is one of the most frequent psychiatric consequences of ischemic stroke. At the same time, clinical trials show increased cerebrovascular accident risk in patients suffering from depression. In the present study on the base of spatiotemporal distribution of metabolites, it was shown that a long-term treatment with a tricyclic antidepressant (imipramine) yielded an appearance of a hypoxia area where one can also find decreased production of mitochondrial ATP. Thus, not only mental disorder but its drug treatment can be the background of stroke development.

Key words: ischemia, arterial system, imipramine, mitochondria, ATP synthesis.