M.A. Kazakova, R.A. Fayzullina, I.I. Akhmetov, E.V. Valeeva, E.S. Egorova

Kazan State Medical University, 49 Butlerov Str., Kazan, Russian Federation, 420012

  Kazakova M.A. — Assistant Lecturer of the Department of Propedeutics of Children’s Diseases and Faculty Pediatrics with a course in children’s diseases of Therapy Faculty, tel. (843) 236-71-72, е-mail: [email protected]

Fayzullina R.A. — Doc. Med. Sc., Head of the Department of Propedeutics of Children’s Diseases and Faculty Pediatrics with a course in children’s diseases of Therapy Faculty, tel. (843) 236-71-72, е-mail: [email protected]

Akhmetov I.I. — Doc. Med. Sc., Head of the Department of Molecular Genetics of the Central scientific-research laboratory, tel. (843) 236-71-72, е-mail: [email protected]Valeeva Elena Valeryevna — Junior Researcher of the Central scientific-research laboratory, tel. (843) 236-71-72, е-mail: [email protected]

Egorova E.S.  — Junior Researcher of the Central scientific-research laboratory, tel. (843) 236-71-72, е-mail: [email protected]

The article was submitted on: 19 February 2018, accepted for publication on: 13 April 2018

 The study of the polymorphism of the IL6 gene from biopsy specimens of duodenal in schoolchildren was carried out. DNA genes were isolated from biopsy samples of duodenal with sorbent method, genetic typing was carried out with PCR method. As a result of our study, it was found that the frequency of occurrence of the GG genotype in patients with chronic gastroduodenitis combined with chronic cholecystitis is 1.5 times higher than that in patients with combined pathology of the gastroduodenal zone and functional disorders of the gallbladder. The frequency of occurrence of the CC genotype in patients with isolated chronic gastroduodenitis was 43%, in the group of patients with pathology of the gastroduodenal zone in combination with organic lesions of the biliary tract, this genotype was not found. In our study, the GG genotype was more common in patients with organic pathology of the biliary tract associated with H. pylori. Thus, we have found the prevalence of the GG polymorphism in the IL6-174 gene in patients with combined organic pathology of the gastroduodenal and biliary zone in children associated with H. pylori.

Keywords. Polymorphism of IL6 174 G/C gene, Helicobacter pylori, chronic gastroduodenitis, chronic cholecystitis, bile duct dysfunction, children.

(For citation: M.A. Kazakova, R.A. Fayzullina, I.I. Akhmetov, E.V. Valeeva, E.S. Egorova. Polymorphism of the 174 g / c il6 gene in children with combined gastroduodenal and biliary pathology associated with Helicobacter Pylori. Practical Medicine. 2018)

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