N.F. UTYAGULOVA², T.R. GALIULLIN¹, O.V. LYUTOV, K.Z. BAKHTIYAROVA¹

¹Bashkortostan State Medical University, Russian Federation, Ufa

²Republic Children’s Clinical Hospital, Russian Federation, Ufa

Contact details:

Bakhtiyarova K.Z, MD, Professor of the Neurology Department

Address: 3 Lenin St., Russian Federation, Ufa, 450008, tel.: +7 (347) 248-23-01, e-mail: bsmu-neuro@yandex.ru

The purpose — to explore prevalence and clinical particularities of the pediatric multiple sclerosis in Bashkortostan Republic.

Material and methods. The data of 21 children with multiple sclerosis were analyzed. The data were provided by the Republican Centre of the multiple sclerosis (Ufa) and outpatient records of the Kuvatov’s Republican Clinical Hospital (Ufa). All children were examined out patiently at the Neurology Department at the Republican Children’s Clinical Hospital (Ufa) and the polyclinics of the Republican Clinical Hospital (Ufa). Diagnosis «multiple sclerosis» (MS) was issued by McDonald criteria (2017).

Results. MS affects female children more often. City residents are hit much more frequently. The onset occurs among senior schoolchildren in most cases. Most of the patients have remitting course of MS.

Conclusion. The main epidemiological indicators of childhood onset MS in the Republic of Bashkortostan are comparable to those in neighboring regions of Russia, and the observed changes reflect the global trends. The study confirmed the findings of other authors on the main characteristics of childhood MS. Pediatric patients require a specialized approach to the diagnosis and careful monitoring of neurological symptoms in order to timely identify multiple sclerosis.

Key words: multiple sclerosis, children.

REFERENCES

1. Metkechekova Yu.V. Nosological structure of demyelinating diseases of the central nervous system in children in the Moscow region with a dynamic assessment of data for 2016–2018. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. Spetsvypusk, 2018, no. 8 (2), p. 60 (in Russ.).
2. Sivertseva S.A., Bykova O.V., Bakhtiyarova K.Z. et al. Clinical cases of multiple sclerosis in children with infantile cerebral palsy. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. Spetsvypusk, 2018, no. 8 (2), pp. 55–61 (in Russ.).
3. Kristen M. Krysko, Graves J., Rensel M. Use of newer disease-modifying therapies in pediatric multiple sclerosis in the US. Neurology, 2018, vol. 91 (19), pp. 1778–1787.
4. Magzhanov R.V., Bakhtiyarova K.Z., Baybazarova F.M., Akhmetova V.M., Khamitova G.R. Observation of a patient with early onset of multiple sclerosis. Meditsinskiy vestnik Bashkortostana, 2007, p. 57 (in Russ.).
5. Bakhtiyarova K.Z., Magzhanov R.V. Retrospective observation of patients with early onset of multiple sclerosis. Nevrologicheskiy vestnik, 2006, vol. XXXVIII, iss. 3–4, pp. 46–49 (in Russ.).
6. Popova E.V., Boyko A.N., Bykova O.V., Nankina I.G., Batysheva T.T. Experience of using the Russian biosimilar interferon beta-1b in the treatment of multiple sclerosis in children. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2016, № 116 (6), pp. 73–75 (in Russ.).
7. An Q., 7. Fan CH., 7. Xu SM. Childhood multiple sclerosis: clinical features and recent developments on treatment choices and outcomes. European Review for Medical and Pharmacological Sciences, 2018, no. 22 (17), pp. 5747–5754.
8. Gorman M.P., Healy V.S., Polgar-Turcsanyi M., Chitnis T. Increased relapse rate in pediatric-onset compared with adult-onset multiple sclerosis. Archives of neurology, 2009, pp. 54–59.
9. Bykova O.V., Nankina I.A., Drozdova I.M., Kvasova O.V., Batysheva T.T., Boyko A.N. Drugs that change the course of multiple sclerosis in children and adolescents. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. Spetsvypusk, 2016, no. 116 (2), pp. 44–53 (in Russ.).
10. Boyko A.N., Bykova O.V., Sivertseva S.A. Pathogenetic treatment of multiple sclerosis in children and adolescents. Prakticheskaya meditsina, 2017, no. 1 (102), pp. 28–34 (in Russ.).
11. Khabirov F.A., Babicheva N.N., Esin R.G., Kochergina O.S., Granatov E.V., Khaybullin T.I. Clinical and socio-demographic characteristics of multiple sclerosis in the Republic of Tatarstan. Prakticheskaya meditsina, 2013, no. 1, pp. 15–17 (in Russ.).