Patogenetic influence of nitric oxide and lipid peroxidation processes during natural HCV-infection and ozone therapy
N.V. GALEYEVA, V.Kh. FAZYLOV, I.Kh. VALEYEVA
Kazan State Medical University, 49 Butlerov St., Kazan, Russian Federation, 420012
Galeyeva N.V. — Assistant Lecturer of the Department of Infectious Diseases, tel. +7-919-640-16-62, e-mail: Nelli_04@mail.ru
Fazylov V.Kh. — D. Med. Sc., Professor, Head of the Department of Infectious Diseases, tel. +7-917-254-89-97, e-mail: vildan47@rambler.ru
Valeyeva I.Kh. — D. Biol. Sc., Seniour Researcher of Central Scientific Research Laboratory, tel. +7-917-232-28-42, e-mail: valeeva.ildaria@yandex.ru
The article presents the results of investigation of nitric oxide and lipid peroxidation (LP) products in blood serum in 125 patients with chronic HCV-infection. The nitric oxide level and LP processes are studied during natural HCV-infection process, depending on viral loading and infection process activity. The dynamics of nitric oxide and lipid peroxidation products is shown during ozone therapy.
Key words: chronic HCV-infection, nitric oxide (NO), ozone therapy, lipid peroxidation.
REFERENCES
1. Sayfutdinov R.G. Role of nitric oxide in internal diseases (literature review). Vestnik sovremennoy klinicheskoy meditsiny, 2009, vol. 2, no. 3, pp. 45-53 (in Russ.).
2. Proskuryakov S.Ya., Biketov S.I., Ivannikov A.I. Nitric oxide in the mechanisms of the pathogenesis of intracellular infections. Immunologiya, 2000, no. 4, pp. 9-20 (in Russ.).
3. Lubrano V., Vassalle C., Blandizzi C. et al. The effect of lipoproteins on endotelial nitric oxside synthase is modulated bi lipoperoxides. Eur. Clin. Invest., 2003, vol. 33, pp. 117-125.
4. Lebedev V.V., Bondarenko I.N., Avdeeva M.G., Strikhanov K.S., Shubich M.G. The clinical significance of the level of nitric oxide in the differential diagnosis of acute and chronic viral and toxic liver damage. Infektsionnye bolezni, 2010, vol. 8, no. 1, pp. 19-24 (in Russ.).
5. Vinogradova N.A. Monooksid azota i sintez al’buminov pri virusnykh gepatitakh [Nitrogen monoxide and synthesis of albumin in viral hepatitis]. Materialy VI Ros. S»ezda vrachey infekts. Saint Petersburg, 2003. Pp. 69-70.
6. Vladimirov Yu.A. Archakov A.I. Perekisnoe okislenie lipidov v biologicheskikh membranakh [Lipid peroxidation in biological membranes]. Moscow: Nauka, 1972. P. 252.
7. Sklyar L.F., Markelova E.V., Polushin O.G., Tokmalaev A.K., Popov A.F. Khronicheskaya HCV-infektsiya: sovremennye immunomorfologicheskie aspekty [Chronic HCV-infection: immunomorfologicheskie modern aspects]. Moscow: Izdatel’stvo rossiyskogo universiteta druzhby narodov, 2006. P. 214.
8. Zmyzgova A.V., Maksimov V.A. Klinicheskie aspekty ozonoterapii [Clinical aspects of ozone therapy]. Moscow: Meditsina, 2003. P. 287.
9. Bocci V. Biological and clinical effects of ozone. Has ozone therapy a future in medicine? British journal of Biomedikal Science, 1999, vol. 56, no. 4, pp. 270-279.
10. Galeeva N.V. Ozonoterapiya pri virusnykh gepatitakh A, V i S: avtoreferat. dis. … kand. med. nauk [Ozone therapy for viral hepatitis A, B and C: the dissertation of candidate. Med. Sciences]. Kazan, 2005. P. 20.
11. Golikov P.P., Nikolaeva N.Yu., Gavrilenko I.A. et al. Nitric oxide and lipid peroxidation as factors of endogenous intoxication in case of emergency. Patologicheskaya fiziologiya i eksperimental’naya terapiya, 2001, no. 2, pp. 6-9 (in Russ.).
12. Golikov I.P. Oksid azota v klinike neotlozhnykh zabolevaniy [Nitric oxide in the hospital emergency diseases]. Moscow: ID Medpraktika, 2004.
13. Guevara I., Iwanejko J., Dembinska-Kiec A. et al. Determination of nitrite/nitrate in human biological material by the simple Griess reaction. Clin. Chim. Acta, 1998, Jun. 22, 274 (2), pp. 177-188.
14. Gavrilov V.B., Mishkorudnaya M.I. Spectrophotometric determination of hydroperoxides, plasma lipid. Laboratornoe delo, 1983, no. 3, pp. 33-35 (in Russ.).
15. Korolyuk M.A., Ivanova L.I., Mayorova I.G., Tokarev V.E. Method for determination of catalase activity. Laboratornoe delo, 1988, no. 1, pp. 16-19 (in Russ.).
16. Ten E.V. Rapid method for the determination of serum ceruloplasmin. Laboratornoe delo, 1984, no. 6, pp. 334-335 (in Russ.).
17. Chang K.M. Immunopathogenesis of hepatitis C virus infection. Clin. Liver Dis., 2003, no. 7, pp. 89-105 (in Russ.).
18. Martynova T.V., Alekseeva I.N., Bryzgina T.M. et al. Influence of blockers of NO synthase in the immune response, monooxygenase activity and lipid peroxidation in the spleen of mice. Meditsinskaya immunologiya, 2003, no. 4, p. 206.
19. Ratnikova L.I., Mel’nikov I.V. Value of nitric oxide in hepatocyte injury during liver pathology. Epidemiologiya i infektsionnye bolezni, 2002, no. 6, pp. 50-54 (in Russ.).
20. Enaleeva D.Sh., Fazylov V.Kh., Sozinov A.S. Khronicheskie virusnye gepatity V, S i D [Chronic viral hepatitis B, C and D]. Moscow: MED press-inform, 2011. P. 463.