N.M. GRUBER, E.K. VALEEV, A.A. SHULMAN

Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan, 138 Orenburgskiy Trakt, Kazan, Russian Federation, 420064

 Gruber N.M. ― PhD (medicine), Leading Researcher, tel. (843) 237-35-23, e-mail: rkb_nauka@rambler.ru

Valeev E.K. ― D. Sc. (medicine), Senior Researcher, tel. (843) 237-35-23, e-mail: rkb_nauka@rambler.ru

Shulman A.A. ― Senior Researcher, tel. (843) 237-35-23, e-mail: rkb_nauka@rambler.ru Severe mechanical injuries cause metabolic shifts in life support systems of the injured people, which manifest themselves by a sharp change in functional and biochemical constants and reflect different periods of traumatic illness. Periods of traumatic illness coincide in time with phases of bone regeneration, and disruption of adaptation in the early stages of traumatic illness affects the course of reparative processes.

Key words: traumatic disease, metabolic disorders, bone regeneration. 

(For citation: Gruber N.M., Valeev E.K., Shulman A.A. Pathogenetic mechanisms of traumatic disease with mechanical damages. Practical Medicine. 2018)

REFERENCES

1. Seleznev S.A., Khudayberenov G.S. Travmaticheskaya boleznʹ [Traumatic disease]. Ashkhabad: YLYM, 1984. 223 p.
2. Korzh A.A., Belous A.M., Pankov A.M. Reparativnaya regeneratsiya kosti [Reparative bone regeneration]. Moscow: Meditsina, 1972. 231 p.
3. Vybornov Yu.D., Gurevich A.I., Nemsadze V.P. et al. Ulʹtrazvukovaya diagnostika konsolidatsii perelomov i narusheniy reparativnogo osteogeneza u detey [Ultrasound diagnosis of consolidation of fractures and disorders of reparative osteogenesis in children]. Sovershenstvovanie ortopedo-travmatologicheskoy pomoshchi detyam: mat-ly simpoziuma detskikh travmatologov-ortopedov Rossii s mezhdunarodnym uchastiem. Saint Peterburg, 2008. Pp. 69-71.
4. Travmaticheskaya boleznʹ i ee oslozhneniya, pod red. S.A. Selezneva, S.F. Bagnenko, Yu.P. Shapoty [Traumatic disease and its complications. Ed. by S.A. Seleznev, S.F. Bagnenko, Yu.P. Shapota]. Saint Petersburg: Politekhnika, 2004. 414 p.
5. Gubanova A.I. Osobennosti otnositelʹnykh izmeneniy regionarnogo krovenapolneniya pri krovopotere [Features of the relative changes in regional blood supply during blood loss]. Osobennosti patogeneza i terapii shoka pri travmakh razlichnoy lokalizatsii: mat-ly simpoziuma, 17-18 maya 1977 g. Leningrad, 1977. Pp. 138-139.
6. Dumbadze G.G., Khvedelidze G.V., Dzhugeli I.S. et al. Sostoyanie obshchego gazoobmena i nekotorykh prisposobitelʹnykh mekhanizmov pri ostrykh krovopoteryakh [The state of general gas exchange and some adaptive mechanisms in acute blood loss]. Osobennosti patogeneza i terapii shoka pri travmakh razlichnoy lokalizatsii: mat-ly simpoziuma 17-18 maya 1977 g. Leningrad, 1977. Pp. 139-141.
7. Gruber N.M., Derbysheva V.G. Metabolic blood shifts in combined traumatic brain injury. Sovrem. iskusstvo meditsiny, 2012, no. 5, pp. 37-41 (in Russ.).
8. Minchenko B.I. Biochemical indicators of metabolic bone disorders. Klin. lab. diagn, 1999, no.1, pp. 8-15 (in Russ.).
9. Tkachuk E.A., Luneva S.N., Stogov M.V. Biochemical indices of blood serum as markers of complications in closed fractures of the bones of the tibia. Klin. lab. diagn, 2011, no. 10, p. 43 (in Russ.).
10. Kulagin V.K., Krivoruchko B.I. Osobennosti patogeneza shoka pri travmakh razlichnoy lokalizatsii [Features of the pathogenesis of shock in injuries of various localization]. Osobennosti patogeneza i terapii shoka pri travmakh razlichnoy lokalizatsii: mat-ly simpoziuma 17-18 maya 1977 g. Leningrad, 1977. Pp. 27-30.
11. Gruber N.M. Svertyvayushchaya sistema krovi i neyromediatory pri tyazheloy sochetannoy travme: avtoref. dis. … kand. biol. nauk [Coagulant system of blood and neurotransmitters for severe concomitant injury. Synopsis of dis. PhD biol. sciences]. Tomsk, 1988. 18 p. Bibliogr.: 6 names.
12. Tsushko V.S. Taktika laboratornoy diagnostiki sindroma DVS [Tactics of laboratory diagnosis of DIC syndrome]. Nekotorye voprosy klinicheskoy i ehksperimentalʹnoy gemokoagulologii: mat-ly nauchno-prakt. konfer. Tyumen, 1984. Pp. 79-81.
13. Nevzorova T.A., Mordakhanova Eh.R., Andreeva I.A. et al. Activation and apoptosis of platelets under the action of pathogenic immune complexes containing platelet factor 4. Geny i kletki, 2015, vol. 10, no. 4, pp. 1-7 (in Russ.).
14. Kudrin V.N., Boldina I.G., Bityukova E.S. Sravnitelʹnaya kharakteristika izmeneniy aktivnosti kisloy fosfatazy v syvorotke krovi pri ostroy krovopotere i mekhanicheskoy travme [Comparative characteristics of changes in serum acid phosphatase activity in acute blood loss and mechanical injury]. Osobennosti patogeneza i terapii shoka pri travmakh razlichnoy lokalizatsii: mat-ly simpoziuma, 17-18 maya 1977 g. Leningrad, 1977. Pp. 146-147.
15. Gruber N.M., Valeev E.K., Shulʹman A.A. et al. Pathogenetic mechanisms of reparative osteogenesis in the case of concomitant trauma. Prakt. med, 2016, vol. 1, no. 4, pp. 79-81 (in Russ.).