I.V. NIKOLAEVA¹, V.A. ANOKHIN¹, Kh.S. KHAERTYNOV¹, D.R. SEMENOVA¹, G.S. SHAIKHIEVA¹, N.N. SKVORTSOVA²

¹Kazan State Medical University, 49 Butlerov Str., Kazan, Russian Federation, 420012

²Republican Clinical Infectious Hospital named after Prof. A.F. Agafonov, 83 Pobeda Pr., Kazan, Russian Federation, 420140

 Nikolaeva I.V. ― D. Med. Sc., Рrofessor of the Department of Children’s Infections, tel. +7-960-037-70-17, e-mail: irinanicolaeva@ mail.ru

Anokhin V.А, D. Med. Sc., Professor, Head of the Department of Children’s Infectious, tel. +7-906-328-17-43, e-mail: аnokhin56@mail.ru

Khaertynov Kh.S. ― Cand. Med. Sc., Associate Professor of the Department of Children’s Infections, tel. +7-903-342-96-27, e-mail: khalit65@rambler.ru

Semenova D.R. ― postgraduate student of the Department of children infections, tel. +7-917-882-94-95, e-mail: nadgy@bk.ru

Shaikhieva G.S. ― postgraduate student of the Department of Children’s Infections, tel. +7-917-245-93-10, e-mail: studentgulya@yandex.ru

Skvortsova N.N. ― bacteriologist, tel. +7-904-660-18-41, e-mail: natalia.skv.67@gmail.com

Retrospective analysis was carried out of 16 cases of sporadic (out-of-hospital) and 15 cases of nosocomial infection in neonates caused by Кlebsiella pneumoniae. In 11 (73%) children with nosocomial infection, neonatal sepsis developed (septic arthritis, osteomyelitis, purulent meningitis with ventriculitis, pneumonia). In 5 (33.3%) children with nosocomial Klebsiella infection, ulcero-necrotic enterocolitis developed. The course of nosocomial Klebsiella infection was complicated by DIC-syndrome ― in 7 (46%), exicosis of 2-3 degree ― in 2 (13.3%), septic shock ― in 2 (13.3%) children. In 73% children with in-hospital infection, thrombocytopenia developed. Lethality was 13%. Preinatal risk factors of nosocomial Klebsiella infection were prematurity (OR=13.125 [1.3-126.3]) and artificial feeding (OR 28 [3.9-196.4]). Hospital strains of Kl. pneumoniae in 100% cases were producers of ESBL and were sensitive to gentamicin, amikacin, emipinem, ertapenem, ciprofloxacin and cefoperazon/ sulbactam.

Key words: Klebsiella infection, neonates, ESBL, sepsis.

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