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  • Non-invasive methods for the diagnosis of liver fibrosis in chronic HCV infection

    Редактор | 2019, Original articles, Practical medicine part 17 №8. 2019 | 28 ноября, 2019

    A.I. FAZULZYANOVA, S.V. TKACHEVA, A.K. KHUSAINOVA, N.F. GAYFUTDINOV, R.I. GULIEV

    Kazan State Medical University of the Ministry of Health of the Russian Federation, Kazan

     Contact:

    Fazulzyanova A.I. ― PhD (medicine), Associate Professor of the Department of Infectious Diseases

    Address: 49 Butlerov Str., Kazan, Russian Federation, 420012, tel. +7-917-877-34-67, e-mail: al-faz@mail.ru

    In the diagnosis of liver fibrosis, the biopsy remains the «gold standard», however today non-invasive methods come to the fore ― determination of serum markers of fibrosis and transient elastometry (TE).

    Objective ― study of indicators of non-invasive methods for evaluating liver fibrosis in patients with chronic HCV infection who received antiviral therapy (AVT).

    Material and methods. A retrospective analysis of case reports of 42 patients with chronic HCV infection who underwent TE before the start of the AVT and 6-12 months after its completion and were calculated 3 fibrosis indices.

    Results. In patients with liver cirrhosis, average TE values of 21.26±1.598 kPa before treatment and 12.094±1.106 kPa 6 months after treatment were observed (p<0.001); AAR index> 1 before treatment in 21%, after ― in 72.7% (p<0.001); APRI index before treatment ≥1.5 in 63%, after ― in 0% (p<0.001); FIB-4 index before treatment ≥1.5 in 84%, after ― in 66% (p<0.001). A strong direct correlation between elastometry and the APRI and FIB-4 indices after treatment was noted (0,86 и 0,82 appropriately).

    Conclusion. Non-invasive methods allow diagnosing severe fibrosis before development of complications and evaluating it in dynamics. The most sensitive fibrosis index is FIB-4.

    Key words: chronic hepatitis C, liver fibrosis, liver cirrhosis, transient elastometry, AAR, APRI, FIB-4.

    (For citation: Fazulzyanova A.I., Tkacheva S.V., Khusainova A.K., Gayfutdinov N.F., Guliev R.I. Non-invasive methods for the diagnosis of liver fibrosis in chronic HCV infection. Practical medicine. 2019. Vol. 17, №8, P. 44-47)

    REFERENCES

    1. Gepatit S [Hepatitis C]. Vsemirnaya organizatsiya zdravookhraneniya, available at: https://www.who.int/ru/news-room/fact-sheets/detail/hepatitis-c (accessed: 15.08.2019).
    2. Ekspert: real’noe kolichestvo nositeley gepatita v tri raza vyshe ofitsial’nykh dannykh [Expert: the actual number of carriers of hepatitis is three times higher than official data]. Medvestnik: portal rossiyskogo vracha (in Russ.), available at: https://medvestnik.ru/content/news/Ekspert-realnoe-kolichestvo-nositelei-gepatita-v-tri-raza-vyshe-oficialnyh-dannyh.html (accessed: 15.08.2019).
    3. Shiff Yudzhin R., Sorrel Maykl F., Meddrey Uillis S. Bolezni pecheni po Shiffu. Tsirroz pecheni i ego oslozhneniya. Transplantatsiya pecheni [Schiff’s liver disease. Cirrhosis of the liver and its complications. Liver transplantation]. Moscow: GEOTAR-Media, 2012. 592 p.
    4. Sheptulina A.F., Shirokova E.N., Ivashkin V.T. Non-invasive diagnosis of liver fibrosis: the role of serum markers. Gepatologiya, 2015, no. 2, pp. 28-40 (in Russ.).
    5. Mitsura V.M., Tereshkov D.B. Indirect markers of liver fibrosis in patients with chronic viral hepatitis B and C. Problemy zdorov’ya i ekologii, 2016, no. 1, pp. 24-29 (in Russ.).
    6. de Ledinghen V., Vergniol J. According to Metavir score: Transient elastography (FibroScan). Gastroenterologie Clin. Bio, 2008, no. 32, rr. 58-67.
    7. European Association for the Study of the Liver, Asociación Latinoamericana para el Estudio del Hígado. EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. Journal of Hepatology, 2015.
    8. Ivashkin V.T., Yushchuk N.D. et al. Rekomendatsii po diagnostike i lecheniyu vzroslykh bol’nykh gepatitom S [Recommendations for the diagnosis and treatment of adult patients with hepatitis C]. Moscow, 2017.
    9. Ivashkin V.T., Gastroenterologiya: natsional’noe rukovodstvo: kratkoe izdanie [Gastroenterology: national leadership: short edition]. Moscow: GEOTAR-Media, 2015. 480 p., available at: http://www.rosmedlib.ru/book/ISBN9785970434086.html
    10. Ann L.B. Williams, Jay H. Hoofnagle. Ratio of serum aspartate to alanine aminotransferase in chronic hepatitis. Relationship to cirrhosis. Gastroenterology, 1988, no. 95, pp. 734-739.
    11. The APRI may be enhanced by the use of the FIBROSpect II in the estimation of fibrosis in chronic hepatitis C. Science Direct, available at: https://www.sciencedirect.com/science/article/pii/S000989810700143X?via%3Dihub (accessed: 15.08.2019).
    12. FIB-4: An inexpensive and accurate marker of fibrosis in HCV infection. Comparison with liver biopsy and fibrotest. AASLD, available at: https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep.21669 (accessed: 15.08.2019).

    Метки: 2019, A.I. FAZULZYANOVA, A.K. KHUSAINOVA, AAR, APRI, chronic hepatitis C, FIB-4, liver cirrhosis, liver fibrosis, N.F. GAYFUTDINOV, Practical medicine part 17 №8. 2019, R.I. GULIEV, S.V. TKACHEVA, transient elastometry

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