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  • New view at clinical and therapeutic aspects of juvenile myoclonic epilepsy

    Редактор | 2019, Literature reviews, Practical medicine part 17 №7. 2019 | 20 ноября, 2019

    R.G. GAMIROVA1, 2, R.M. SHAIMARDANOVA3, R.R. GAMIROVA2, V.F. PRUSAKOV1

     1Kazan State Medical Academy — Branch Campus of RMACPE MH Russia, Kazan

    2Kazan Federal University,  Kazan

    3Сhildren’s Сity Hospital № 8,  Kazan

     Contact details:

    Gamirova R.G. — Ph. D. (medicine), Associate Professor of the Pediatric Neurology Department, Associate Professor of the Department of Fundamentals of Clinical Medicine, Senior Researcher of the Laboratory of Clinical Linguistics

    Address: 11 Mushtari St., Kazan, Russian Federation, 420012, tel.: + 7-917-257-96-44, e-mail: r-gamirov@mail.ru

     The purpose — to analyze relevant information about the etiology, prevalence, clinical features, and the comparative effectiveness of antiepileptic drugs in the treatment of patients with juvenile myoclonic epilepsy (JME).

    Material and methods. We analyzed publications in the available medical databases PubMed, Cochrane Library for the period 1980–2019 concerning epidemiology, pathogenesis, clinics and treatment effectiveness of JME.

    Results. According to the studies, which had predominantly retrospective observational design, valproate monotherapy had shown a better therapeutic effect in JME versus lamotrigine, topiramate, levetiracetam, and carbamazepine. The use of valproic acid in JME is increasingly limited due to its undesirable drug reactions, teratogenicity, and neurotoxicity.

    Conclusion. At present, problems with the management tactics of patients with JME persist, there is a lack of methodologically correctly conducted randomized clinical trials regarding the comparative effectiveness of antiepileptic drugs in this disease.

    Key words: juvenile myoclonic epilepsy, idiopathic generalized epilepsy, treatment of epilepsy, side effects of antiepileptic drugs.

     (For citation: Gamirova R.G., Shaimardanova R.M., Gamirova R.R., V.F. Prusakov V.F. New view at clinical and therapeutic aspects of juvenile myoclonic epilepsy. Practical Medicine. 2019. Vol. 17, № 7, P. 33-37)

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    Метки: 2019, idiopathic generalized epilepsy, juvenile myoclonic epilepsy, Practical medicine part 17 №7. 2019, R.G. GAMIROVA, R.M. SHAIMARDANOVA, R.R. GAMIROVA, side effects of antiepileptic drugs, treatment of epilepsy, V.F. PRUSAKOV

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