R.R. KHAFIZOV¹, B.I. ZAGIDULLIN¹, N.Sh. ZAGIDULLIN², O.I. LEONTYEVA¹, A.Zh. GILMANOV², Sh.Z. ZAGIDULLIN²

¹State Emergency Clinic of Republic Tatarstan, 18 Naberezhnochelninskiy Prospekt, Naberezhnie Chelny, Russian Federation 423803

²Bashkir State Medical University, 3 Lenin St., Ufa, Russian Federation 450000

Khafizov R.R. — doctor of the Department of Roentgen-Surgical Diagnostic and Treatment Techniques, tel. +7-917-436-00-60, e-mail: [email protected]¹

Zagidullin B.I. — Cand. Med. Sc., Head of the Department of Roentgen-Surgical Diagnostic and Treatment Techniques, tel. +7-917-917-55-88, e-mail: [email protected]¹

Zagidullin N.Sh. — D. Med. Sc., Professor of the Department of Propedeutics of Internal Diseases, tel. . +7-962-546-76-22, e-mail: [email protected]²

Leontyeva O.I. — Head of Clinical-Diagnostic Laboratory, tel. +7-960-064-67-66, e-mail: [email protected]¹

Gilmanov A.Zh. — D. Med. Sc., Professor, Head of the Department of Clinical-Laboratory Diagnostics, tel. +7-927-237-55-82, e-mail: [email protected]²

Zagidullin Sh.Z. — D. Med. Sc., Professor, Head of the Department of Propedeutics of Internal Diseases, tel. +7-917-442-48-63, e-mail: [email protected]²

In-time diagnostics of myocardial infarction allows to stratify cardiovascular risk in patients and to determine the outcomes of acute coronary syndrome (ACS). Along with the «classical» (troponin I, TnI; Creatinine MB fraction, CK MB, myoglobin) biomarkers, recently appeared the «new» ones, such as atrial natriuretic peptide (ANP), high sensitive C-reactive protein (hsCRP) and myeloperoxidase (MPO). The research objective was to evaluate the efficacy of ANP, hsCRP and MPO in comparison with the «classical» biomarkers in patients with MI with ST elevation (STEMI). TnI was most sensitive in ACS, it was followed by CK MB and myoglobin and MPO. HsCRP and ANP showed low sensitivity. HsCRP only correlated with the level of «gold standard» diagnostics of ACS TnI and CK MB. Patients with right coronary artery occlusion had lower biomarkers level than with occlusions of other arteries. Identification of biomarkers trends in MI can lead to multi-biomarker panel construction that will increase the accuracy of ACS diagnostics and predict patients with future unfavourable cardiovascular events.

Key words: biomarker, acute coronary syndrome, acute myocardial infarction with ST-elevation, high sensitive C-reactive protein, myeloperoxidase, atrial natriuretic peptide.

 

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