Z.S. ISLAMOV, R.Kh. USMANOV, M.S. GILDIEVA, B.Yu. YUSUPOV, A.A. ABDUVALIEV, Sh. MUSAEVA

Republican Cancer Research Center of the Republic of Uzbekistan, 383 Farabi Str., Tashkent, Republic of Uzbekistan, 100174

 Islamov Z.S. ― Cand. Med. Sc., Head of the Ocular Oncology Department, tel. (+998 71) 246-98-86, e-mail: [email protected]

Usmanov R.Kh. ― resident doctor of the Ocular Oncology Department, tel. (+998 71) 246-98-86, e-mail: [email protected]

Gildieva M.S. ― D. Biol. Sc., Head of the Laboratory of Tumor Biology, tel. (+998 71) 246-98-74, e-mail: [email protected]

Yusupov B.Yu. ― D. Med. Sc., scientific consultant of the Department of Head and Neck Tumors, tel. (+998 71) 246-24-15

Abduvaliev A.A. ― Cand. Med. Sc., Senior Researcher of the Laboratory of Tumor Biology, tel. (+998 71) 246-98-74, е-mail: [email protected]

Musayeva Sh.N. ― Junior Researcher of the Laboratory of Tumor Biology, tel. (+998 71) 246-98-74, е-mail: [email protected]

 The aim of the study was to investigate the biochemical changes in the blood of patients with retinoblastoma before and after organ-preserving therapy in combination with antioxidants. The research group included 25 patients with mono- and bilateral retinoblastoma without severe comorbidity. The patients underwent poly-chemotherapy according to scheme with antioxidant: Etoposide 100 mg/m² (1-3 days), Carboplatine 18.6 mg/kg (1-3 days), antioxidant 1 capsule per day (1-3 days). Development of oncopathology in eyes leads to increasing the level of cholesterol in blood serum, as well as high density lipoproteins and thyroxin concentration

Key words: retinoblastoma, poly-chemotherapy, antioxidants.

REFERENCES

1.Singh S., Ramesh V., Premalatha B., Prashad K.V., Ramadoss K. Alterations in serum lipid profile patterns in oral cancer. J Nat SciBiol Med, 2013, no. 4(2), pp. 374-378

2.Maziere C,  et al. Oxidized low density lipoprotein induces the cyclin-dependent kinase inhibitor p21(waf1) and the tumor suppressor Rb. BiochemBiophys Res Commun, 2002, no. 293(5), pp. 1327-32.

3.Hellrung A., Bertsch T., Sieber C.C., Bollheimer L.C., Girlich C. Thyroid dysfunction in elderly patients. Dtsch Med Wochenschr, 2014, no. 139(49), pp. 2498-2500.