Modern aspects of osteoporosis in children
S.V. MALTSEV1, G.Sh. MANSUROVA2
1Kazan State Medical University, 49 Butlerov St., Kazan, Russian Federation, 420012
2Kazan Federal University, 18 Kremlevskaya St., Kazan, Russian Federation, 420008
Maltsev S.V. — D. Med. Sc., Professor of the Department of Propedeutics of
Children’s Diseases and Faculty Pediatrics, tel. +7-905-314-40-28, e-mail: maltc@mail.ru
Mansurova G.Sh. — Cand. Med. Sc., Associate Professor, Institute for Fundamental Medicine and Biology, tel. +7-917-390-79-20, e-mail: gsm98@mail.ru
Osteoporosis is found in children at different ages, being a topical problem, there are exogenous and endogenous, modifiable and non-modifiable risk factors and causes of developing a primary and secondary osteoporosis in children. The critical age periods can be allocated, which are characterized by a high risk of reducing the mineral density of bones and high probability of fractures. The article presents biological effects of calcium, vitamin D and osteotropic microelements, and their role in osteogenesis and bone remodeling. The results of studying the reduction of the mineral density of bones in children are presented, as well as the data on provision of different age children with vitamin D. the modern directions and recommendations for treating osteoporosis in children are described.
Key words: children, osteoporosis, risk factors, frequency, treatment.
REFERENCES
1. Strukov V.I., Sergeeva-Kondrachenko M.Yu. Aktual’nye problemy osteoporoza [Actual problems of osteoporosis]. Rostra, 2009. P. 342.
2. Mal’tsev S.V., Arkhipova N.N., Shakirova E.M., Kolesnichenko T.V. Features of phosphate-calcium metabolism in neonates and premature infants. Prakticheskaya meditsina, 2009, no. 7 (39), pp. 9-13 (in Russ.).
3. Shcheplyagina I.A., Moiseeva T.Yu., Kovalenko T.V. Osteopeniya u detey diagnostika, profilaktika i korrektsiya. Posobie dlya vrachey [Osteopenia in children diagnosis, prevention and correction. Manual for physicians]. Moscow, 2005. 40 p.
4. Korovina N.A., Svintsitskaya V.I. Options osteopenia with tubulointerstitial kidney diseases in children. Pediatriya, 2010, no. 6, pp. 12-16 (in Russ.).
5. Mal’tsev S.V., Arkhipova N.N., Shakirova E.M. Vitamin D, kal’tsiy i fosfaty u zdorovykh detey i pri patologii [Vitamin D, calcium and phosphate in healthy children and in pathology]. Kazan, 2012. 120 p.
6. Nauchno-prakticheskaya programma “Defitsit kal’tsiya i osteopenicheskie sostoyaniya u detey: diagnostika, lechenie, profilaktika”, pod red. N.A. Korovinoy i V.A. Peterkovoy [Scientific-practical program “Calcium deficiency and osteopenic conditions in children: diagnosis, treatment, prevention”. Ed. by O.N. Korovina and V.A. Peterkova]. Moscow: Mezhdunarodnyy fond okhrany materi i rebenka, 2006. 46 p.
7. Mal’tsev S.V., Mansurova G.Sh., Kolesnichenko T.V., Zotov N.A. Bone mineral density of children in different age periods. Prakticheskaya meditsina, 2013, no. 6 (75), pp. 106-108 (in Russ.).
8. Canalis E., Mazziotti G., Giustina A., Bilezikian J.P. Glucocorticoid induced osteoporosis: pathophysiology and therapy. Osteoporos Int, 2007, vol. 18(10), rr. 1319-1328.
9. Osteoporoz. Diagnostika, profilaktika i lechenie: klinicheskie rekomendatsii, pod red. O. Lesnyak, L. Benevolenskoy [Osteoporosis. Diagnosis, prevention and treatment: clinical guidelines. Ed. by A. Lesniak, L. Benevolenskaya]. Moscow: GEOTAR-Media, 2010. 272 p.
10. Hogler W., Shaw N. Childhood Growth Hormone Deficiency, Bone Density, Structures and Fractures: Scrutinizing the Evidence. Clin.Endocrinol, 2010, vol. 72(3), rr. 281-289.
11. Cannell J.J., Hollis B.W. Use of Vitamin D in Clinical Practice. Alternative Med. Review, 2008, vol. 13(1), rr. 6-20.
12. Korovina N.A., Tvorogova T.N. Prevention of osteopenia in children and adolescents with osteoporosis risk. Lechashchiy vrach, 2006, 07/06, rr. 21-29 (in Russ.), available at: http://www.lvrach.ru/2006/07/4534208/ (accessed: 22.07.2015).
13. Chirkin A.A., Danchenko E.O. Biokhimiya. Rukovodstvo [Biochemistry. Manual]. Moscow: Meditsinskaya literatura, 2010. Pp. 497-498.
14. Wacker M., Holick M.F. Vitamin D-effects on skeletal and extra skeletal health and the need for supplementation. Nutrients, 2013, vol. 5(1), rr. 111-148.
15. Nieves J.W. Supplement: women and micronutrients: addressing the gap throughout the life cycle. Osteoporosis: the role of micronutrients. Am. J. Clin. Nutr, 2005, vol. 81(5), rr. 1232-1239.
16. Mosekilde L. Vitamin D and the Elderly. Clin. Endocrinol, 2005, vol. 623, rr. 265-281.
17. Reusheva S.V., Panicheva E.A., Pastukhova S.Yu., Reushev M.Yu. The value of vitamin D deficiency in the development of human diseases. Uspekhi sovremennogo estestvoznaniya, 2013, no. 11, rr. 27-31 (in Russ.).
18. Spirichev V.B. On the biological effects of vitamin D. Pediatriya, 2011, no. 90(6), pp. 113-119 (in Russ.).
19. Natsional’naya programma “Nedostatochnost’ vitamina D u detey i podrostkov v Rossiyskoy Federatsii: sovremennye podkhody k korrektsii” [The national program “Vitamin D deficiency in children and adolescents in the Russian Federation: modern approaches to correction”]. Moscow, 2015. 112 p.
20. Natarajan C.R., Sankar M.J., Agarwal R., Pratar O.T., Jain V., Gupta N., Gupta A.K., Deorari A.K., Paul V.K., Sreenivas V. Trial of daily vitamin D supplemention in preterm infants. Pediatrics, 2014, 133 (3), rr. 628-634.
21. Hedges T. Sun safety: what are the health messages?. J. Royal Soc. Promot. Health, 2008, vol. 128(4), rr. 164-169.
22. Stoch S.A., Zajic S., Stone J. et al. Effect of the cathepsin K inhibitor odanacatib on bone resorption biomarkers in healthy postmenopausal women: two double-blind, randomized, placebo-controlled phase I studies. J Clin Pharmacol Ther, 2009, vol. 86(2), rr. 175-182.
23. Stoch S.A., Zajic S., Stone J. et al. Effect of the cathepsin K inhibitor odanacatib on bone resorption biomarkers in healthy postmenopausal women: two double-blind, randomized, placebo-controlled phase I studies. J Clin Pharmacol Ther, 2009, vol. 86(2), rr. 175-182.