Microperimetry as a new technique for diagnostics of central scotoma in optic neuritis with multiple sclerosis
E.E. IOYLEVA, M.S. KRIVOSHEEVA
The S. Fyodorov Eye Microsurgery Federal State Institution, 59a Beskudnikovsy blvr Str., Moscow, Russian Federation, 127474
Ioyleva E.E. ― D. Med. Sc., Professor of the Department of Eye Diseases, tel. (499) 488-85-24, e-mail: [email protected]
Krivosheeva M.S. ― ophthalmologist, postgraduate student, tel. (499) 488-85-24, e-mail: [email protected]
The study involved 31 patients with optic neuritis as a consequence of multiple sclerosis (MS). With the microperimetry technique, we evaluated the average retinal sensitivity, stability of fixation during the time period, describing the quality and size of the revealed vision defects. An algorithm of medical examination of MS patients was determined: macula 12º 10 dB using Goldmann III stimulus in the automatic mode, with registration protocol «9 in 1». The fixation mark (central or circular) was selected individually depending on visual acuity. The examination according to the proposed algorithm revealed the defects of the central field of view of various sizes in all patients. The research has for the first time showed that microperimetry technique allows to reveal cntral scotomas of all sizes in optic neuritis with the MS. For the first time, an algorithm was developed for examination for optic neuritis with the MS in patients with different visual acuity. The method has application prospects for diagnosing the diseases of the visual analyzer.
Key words: microperimetry, optic neuritis, multiple sclerosis, central scotoma.
REFERENCES
- Gusev E.I., Zavalishin I.A., Boyko A.N. Rasseyannyy skleroz, klinicheskoe rukovodstvo [Multiple sclerosis, clinical guidelines]. Moscow, 2011. 782 p.
- Pedanova E.K. Mikroperimetriya v otsenke funktsional’nogo sostoyaniya i kompleksnom prognozirovanii rezul’tatov khirurgicheskogo lecheniya patsientov s idiopaticheskim makulyarnom razryvom: dis. … kand. med. nauk, GU “Mezhotraslevoy NTK “Mikrokhirurgiya glaza” [Microperimetry in the evaluation of the functional state of the complex and forecasting of results of surgical treatment of patients with idiopathic macular rupture. Synopsis of dis. PhD med. sciences]. Moscow, 2009. 105 p.
- Ioyleva E., Krivosheeva M. Microperimetry in the diagnosis of the first manifestation of optic neuritis in multiple sclerosis. Journal of the Neurological Sciences, 2015, vol. 357, p. e 47.
- Ioyleva E.E., Krivosheeva M.S. Unilateral swelling of the optic nerve: features of differential diagnostics. Tavricheskiy mediko-biologicheskiy vestnik, 2013, no. 3, p. 2, pp. 166-170 (in Russ.).
- Ioyleva E.E., Krivosheeva M.S., Smirnova M.A. A survey of patients with optic neuritis in the opening of multiple sclerosis. Vestnik OGU, 2014, no. 12, pp. 143-146 (in Russ.).
- Barkhof F., Filippi M., Miller D.H., et al. Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis. Brain, 1997, vol. 120, pp. 2059-2069.
- Lisochkina A.B., Nechiporenko P.A. Microperimetry — advantages of the method and practical application. Oftal’mol. vedomosti, 2009, vol. 2, no. 1, pp. 18-22 (in Russ.).
- Sawa M., Gomi F., Toyoda A., et al. A microperimeter that provides fixation pattern and retinal sensitivity measurement. Jpn. J. Ophthalmol, 2006, vol. 50, pp. 111-115.
- Doga A.B., Kachalina G.F., Pedanova E.K. Vozmozhnosti mikroperimetrii v retinal’noy lazernoy khirurgii [Features Microperimetry in retinal laser surgery]. Noveyshie dostizheniya v lechenii i diagnostike glaznykh zabolevaniy: Materialy 11 ezhegodnoy konferentsii. Moscow, 2007. Pp. 12-13.
- Romano M.R., Angi M., Romano F. Macular sensitivity change in multiple sclerosis followed with microperimetry. Eur. J. Ophthalmol, 2007, vol. 17, pp. 441-444.
- Ioyleva E.E. Krivosheeva M.S. Sposob ranney diagnostiki retrobul’barnogo nevrita pri debyute rasseyannogo skleroza no. 2548511 prioritet ot 20.03.2015 [The method of early diagnosis of optic neuritis with multiple sclerosis debut priority №2548511 from 20.03.2015].
- Koshelev D.I., Sirotkina I.V., Lebedev I.V. Regulation fixing the field and significant characteristics of eye movements in violation of central vision. Vestnik OGU, 2009, no. 12, pp. 74-77 (in Russ.).