V.S. KUVAEV, YU.V. BOGDANOVA, M.A. SELIKHOVA, V.I. KUPAEV, I.L. DAVYDKIN
Samara State Medical University
Samara Regional Clinical Hospital named after M.I. Kalinin

This is a study of microcirculatory disorders and indicators of endothelial dysfunction in smokers (without COPD) and patients with chronic obstructive pulmonary disease of stage I and II using laser doppler flowmetry with measurement of the ankle-brachial index, lipid metabolism indicators, level of the C-reactive protein, and the Willebrand factor. It was found that smokers with no signs of COPD have dyslipidemia without significant systemic inflammation and endothelial dysfunction. Patients with chronic obstructive pulmonary disease on the background of severe dyslipidemia at an early stage of the disease have a different marker of endothelial damage, mainly C-reactive protein and the Willebrand factor, indicators of microcirculation reflecting the activation of regulatory mechanisms, the growth of stagnation and arterial spasm in the microvasculature.

Key words:  chronic obstructive pulmonary disease, microcirculation. 

REFERENCES

1. Chuchalin A.G. Aktual’nye voprosy pul’monologii // RMZh. — 2004. — № 2. — s. 727.

2. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, mange met, end prevention of chronic obstructive pulmonary disease. — 2011. — p. 36.

3. Hansel A.L., Walk J.A., Soriano J.B. What do chronic obstructive pulmonary disease patients die from? A multiple cause coding analysis // Eur. Respir. J. — 2003. — № 22 (5). — P. 809-814.

4. Sin D.D., Man S.F. Why are the patients with chronic obstructive pulmonary disease at increased risk of cardiovascular disease? The potential role of systemic inflammation in cronic obstructive pulmonary disease // Circulation. — 2003. — № 107 (11). — P. 1514-1519.

5. Karpov Ju.A., Sorokin E.V., Fomicheva O.A. Vospalenie i ateroskleroz: sostojanie problemy i nereshennye voprosy // Serdce. — 2003. — T. 2, № 4 (10). — S. 190-192.

6. Endemann D.H., Schiffrin E.L. Endothelial dysfunction // J Am Soc. Nephrol. — 2004 Aug. — № 15 (8). — P. 1983-1992.

7. Tousoulis D, Charakida M. Stefanadis Endothelial function and inflammation coronary artery disease // Hec. — 2005. — № 92. — P. 441-444.

8. Kanishheva E.M., Fedorovich A.A. Vozmozhnost’ ocenki sostojanija mikrocirkuljatornogo rusla i stenok krupnyh sosudov // Serdce: zhurnal dlja praktikujushhih vrachej. — 2010. — T. 9, № 1 (51). — S. 65-70.

9. Danilenko S.A., Landyshev Ju.S. Mikrogemocirkuljatornye narushenija v slizistoj obolochke bronhov pri hronicheskoj obstruktivnoj bolezni legkih // Regionarnoe krovoobrashhenie i mikrocirkuljacija. — 2010. — T. 9, № 1 (33). — S. 38-41.

10. Zhulina N.I., Smirnova O.V. Dinamika pokazatelej mikrocirkuljacii pri vosstanovitel’nom lechenii bol’nyh starshej vozrastnoj gruppy s hronicheskoj obstruktivnoj bolezn’ju legkih // Klinicheskaja gerontologija. — 2006. — T. 12, № 9 — S. 25-26.

11. Fedorova T.A., Mamonov A.V., Masjakin P.N. Sravnitel’nye vozmozhnosti razlichnyh metodov issledovanija mikrocirkuljacii u bol’nyh hronicheskoj obstruktivnoj bolezn’ju legkih // Mikrocirkuljacija. — 2007. — № 1. — S. 55-60

12. Jacenko M.K., Voronina L.P., Trubnikov G.A. Kozhnaja mikrocirkuljacija u bol’nyh s bronhial’noj astmoj i hronicheskoj obstruktivnoj bolezn’ju legkih // Uspehi sovremennogo estestvoznanija. — 2005. — № 12. — S. 12

13. Lazernaja dopplerovskaja floumetrija mikrocirkuljacii krovi. Rukovodstvo dlja vrachej / Pod red. A.I. Krupatkina, V.V. Sidorova. — M.: Medicina, 2005. — S. 125.

14. Ratanakorn D., Keandoungchun J., Tegeler C.H. Prevalence and Association between Risk Factors, Stroke Subtypes, and Abnormal Ankle Brachial Index in Acute Ischemic Stroke // J Stroke Cerebrovasc Dis. — 2011 Jan. — № 12. — P. 145-147.

15. Mills N.L., Miller J.J., Anand A. et al. Increased arterial stiffness in patients with chronic obstructive pulmonary disease: a mechanism for increased cardiovascular risk // Thorax. — 2008 Apr. — № 63 (4). — P. 306-311

16. Mikrocirkuljacija v kardiologii // Rukovodstvo dlja vrachej / Pod red. V.I. Makolkina. — M., 2004. — S. 133.