S.I. MALYAVSKAYA, A.V. LEBEDEV, G.N. KOSTROVA, V.A. FOKINA, V.A. SEMENOV

Northern State Medical University, Arkhangelsk

 Contact details:

Malyavskaya S.I. — MD, Professor, Head of the Department of Pediatrics, Vice Rector on R&D

Address: 51 Troitsky prospekt, Arkhangelsk, Russian Federation, 163069, tel.: +7 (8182) 28-57-83, e-mail: Malyavskaya@yandex.ru

 To determine the features of disorders and the relationship of the blood lipid spectrum, indicators of peroxidation and insulin resistance in adolescents with fatty hepatosis, a single-stage study was conducted of a sample of 58 adolescents from Arkhangelsk aged 16–17 y. o. who have instrumental signs of fatty hepatosis according to ultrasound diagnostics. The comparison group consisted of 219 adolescents from Arkhangelsk who did not have acute and chronic diseases at the time of the examination. The results of the study showed higher average values of total lipid peroxidation, HOMA index, insulin, glucose, triglycerides, total cholesterol, low-density lipoprotein cholesterol and lower high-density lipoprotein cholesterol in the group of adolescents with fatty hepatosis than in the comparison group and the presence of a correlation of the HOMA index with the level of total lipid peroxidation, triglycerides and the presence of dyslipidemia (r = 0.53; 0.44; and 0.31; p < 0.05). Thus, when detecting fatty hepatosis in adolescents during diagnostic and corrective measures, it is necessary to take into account the possibility of formation and interrelation of the following pathogenetic factors of non-alcoholic fatty liver disease: insulin resistance, lipid peroxidation and dyslipidemia.

Key words: non-alcoholic fatty liver disease, fatty hepatosis, adolescents, insulin resistance, lipid peroxidation, dyslipidemia.

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