T.P. MAKAROVA, Yu.S. MELNIKOVA

Kazan State Medical University, 49 Butlerov St., Kazan, Russian Federation, 420012 

Makarova T.P. — D. Med. Sc., Professor of the Department of Hospital Pediatrics with PR and PE courses, tel. (843) 237-30-37, e-mail: makarova-kgmu@mail.ru

Melnikova Yu.S. — postgraduate student of the Department of Hospital Pediatrics with PR and PE courses, tel. (843) 237-30-37, e-mail: mus87@mail.ru

The review contains information about the importance of endothelial dysfunction in the progression of chronic kidney disease (CKD) in children. The potential mechanisms for the development of endothelial dysfunction in CKD are described, including oxidative stress, defects of arginine metabolism and the reversely connected nitric oxide metabolism, as well as the increased levels of asymmetric dimethylarginine.

Key words: endothelial dysfunction, chronic kidney disease, nitric oxide, oxidative stress, asymmetric dimethylarginine.

 

 

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