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  • Lactase activity as a limiting factor in the use of dairy products in children with celiac disease

    Редактор | 2016, Original articles, Practical medicine 08 (16) Pediatrics | 30 ноября, 2016

    L.Ya. KLIMOV1, M.V. STOYAN1,2, L.M. ABRAMSKAYA1, V.A. KURYANINOVA1,2, V.S. KASHNIKOV1,2, L.D. KOCHNEVA1, D.V. BOBRYSHEV1, A.N. KASYANOVA1, G.S. ANISIMOV3

    1Stavropol State Medical University, 310 Mir Str., Stavropol, Russian Federation, 355017

    2Municipal Children’s Clinical Hospital named after G.K. Filippskiy, 5 Ponomarev Str., Stavropol, Russian Federation, 355002

    3North-Caucasus Federal University, 1 Pushkin Str., Stavropol, Russian Federation, 355009

    Klimov L.Ya. ― Cand. Med. Sc., Head of the Department of Faculty Pediatrics, tel. +7-928-963-02-61, e-mail: klimov_leo@mail.ru

    Stoyan M.V. ― Cand. Med. Sc., Assistant of the Department of Faculty Pediatrics, gastroenterologist, tel. +7-928-244-79-90, e-mail: marina-stoyan@mail.ru

    Abramskaya L.M. ― postgraduate student of the Department of Faculty Pediatrics, tel. +7-938-346-88-96, e-mail: mila-alm@mail.ru

    Kuryaninova V.A. ― Cand. Med. Sc., Assistant of the Department of Children’s Diseases Propedeutics, gastroenterologist, tel. +7-928-293-80-69, e-mail: vichkak@mail.ru

    Kashnikov V.S. ― D. Med. Sc., associate Professor of the Department of Polyclinic Pediatrics, Chief Doctor, tel. (8652) 71-87-39, e-mail: 721771@mail.ru

    Kochneva L.D. ― 4th year student of Pediatrics Faculty, tel. +7-905-442-03-67, e-mail: kochneva.lyubov.96@mail.ru

    Bobryshev D.V. ― Cand. Med. Sc., Head of the Center for Personalized Medicine of Scientific-Innovative Association, tel. +7-962-403-41-77, e-mail: bobryshevRG@yandex.ru

    Kasyanova A.N. ― 6th year student of Pediatrics Faculty, tel. +7-962-005-56-93, e-mail: a.nicolaevnakasjanova@yandex.ru

    Anisimov G.S. ― Cand. Tech. Sc., Head of the Center for Technological Bio-engineering, tel. +7-962-447-84-25, e-mail: ags88@mail.ru

     The article presents the results of the express-method research of the lactase activity in the biopsy of the jejunum mucosa in 50 children with celiac disease, among which 18 (36.0%) were in the acute period and 32 (64.0%) kept a gluten-free diet. Hypolactasia was diagnosed in 75.0% of cases, and its frequency did not significantly differ in children depending on the stage of the disease. The maximum degree of mucosal atrophy of the jejunum (Marsh 3C) was observed in 47.8% of patients with severe hypolactasia. Titer of autoantibodies to transglutaminase (anti-tTG IgA and IgG) is positively correlated with the severity of hypolactasia in children with celiac disease.

    Key words: hypolactasia, lactose, coeliac disease, children, gluten-free diet.

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    Метки: 2016, A.N. KASYANOVA, Children, coeliac disease, D.V. BOBRYSHEV, G.S. ANISIMOV, gluten-free diet, hypolactasia, L.D. KOCHNEVA, L.M. ABRAMSKAYA, L.Ya. KLIMOV, lactose, M.V. STOYAN, Practical medicine 08 (16) Pediatrics, V.A. KURYANINOVA, V.S. KASHNIKOV

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