L.Ya. KLIMOV¹, M.V. STOYAN^1,2, L.M. ABRAMSKAYA¹, V.A. KURYANINOVA^1,2, V.S. KASHNIKOV^1,2, L.D. KOCHNEVA¹, D.V. BOBRYSHEV¹, A.N. KASYANOVA¹, G.S. ANISIMOV³

¹Stavropol State Medical University, 310 Mir Str., Stavropol, Russian Federation, 355017

²Municipal Children’s Clinical Hospital named after G.K. Filippskiy, 5 Ponomarev Str., Stavropol, Russian Federation, 355002

³North-Caucasus Federal University, 1 Pushkin Str., Stavropol, Russian Federation, 355009

Klimov L.Ya. ― Cand. Med. Sc., Head of the Department of Faculty Pediatrics, tel. +7-928-963-02-61, e-mail: [email protected]

Stoyan M.V. ― Cand. Med. Sc., Assistant of the Department of Faculty Pediatrics, gastroenterologist, tel. +7-928-244-79-90, e-mail: [email protected]

Abramskaya L.M. ― postgraduate student of the Department of Faculty Pediatrics, tel. +7-938-346-88-96, e-mail: [email protected]

Kuryaninova V.A. ― Cand. Med. Sc., Assistant of the Department of Children’s Diseases Propedeutics, gastroenterologist, tel. +7-928-293-80-69, e-mail: [email protected]

Kashnikov V.S. ― D. Med. Sc., associate Professor of the Department of Polyclinic Pediatrics, Chief Doctor, tel. (8652) 71-87-39, e-mail: [email protected]

Kochneva L.D. ― 4^th year student of Pediatrics Faculty, tel. +7-905-442-03-67, e-mail: [email protected]

Bobryshev D.V. ― Cand. Med. Sc., Head of the Center for Personalized Medicine of Scientific-Innovative Association, tel. +7-962-403-41-77, e-mail: [email protected]

Kasyanova A.N. ― 6^th year student of Pediatrics Faculty, tel. +7-962-005-56-93, e-mail: [email protected]

Anisimov G.S. ― Cand. Tech. Sc., Head of the Center for Technological Bio-engineering, tel. +7-962-447-84-25, e-mail: [email protected]

 The article presents the results of the express-method research of the lactase activity in the biopsy of the jejunum mucosa in 50 children with celiac disease, among which 18 (36.0%) were in the acute period and 32 (64.0%) kept a gluten-free diet. Hypolactasia was diagnosed in 75.0% of cases, and its frequency did not significantly differ in children depending on the stage of the disease. The maximum degree of mucosal atrophy of the jejunum (Marsh 3C) was observed in 47.8% of patients with severe hypolactasia. Titer of autoantibodies to transglutaminase (anti-tTG IgA and IgG) is positively correlated with the severity of hypolactasia in children with celiac disease.

Key words: hypolactasia, lactose, coeliac disease, children, gluten-free diet.

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