I.S. LIPATOV, N.V. MARTYNOVA, YU.V. TEZIKOV

Samara State Medical University, 89 Chapayevskaya Str., Samara, Russian Federation, 443099

Lipatov I.S. — D. Med. Sc., Professor of the Department of Obstetrics and Gynecology No. 1, tel. +7-927-262-92-70, e-mail: i.lipatoff2012@yandex.ru

Martynova N.V. — resident doctor of the Department of Obstetrics and Gynecology No. 1, tel. +7-937-065-45-53, e-mail: nadya-martynova@yandex.ru

Tezikov Y.V. — D. Med. Sc., Professor, Head of the Department of Obstetrics and Gynecology No. 1, tel. +7-927-685-44-85, e-mail: yra.75@inbox.ru

The article presents data on a comprehensive survey of 204 pregnant women who were previously treated for genital endometriosis and who received long-term hormonal treatment in the pre-gestational period. The control group consisted of 50 healthy pregnant women. We analyzed the level of inflammatory markers, ant-inflammatory cytokines in blood, of functional activity of endometrium, vascular-endothelial and hemostasis disorders, the amount of СД95+ и ФНОα. The study made it possible to identify, in early pregnancy in women with genital endometriosis, the main laboratory markers of early reproductive losses and late complications of gestation. The operational characteristics of the markers of the embryo-placenta dysfunction syndrome with respect to early reproductive losses indicate their high prognostic significance. The embryoplacental dysfunction detected at the early stages of gestation predetermines the complicated course of late terms: in 79.2 % and 100 % with external and internal endometriosis, respectively. The obtained data justify the need to develop a program of preventive measures, including periconceptional management and prevention of early and late gestational and perinatal complications in women with genital endometriosis.

Key words: endometriosis, early terms of pregnancy, hyperglycemia, endothelial-hemostasis dysfunction, systemic inflammatory response, functional endometrial failure.

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