Issues of neurodegeneration and demyelination in MS according to optical coherence tomography
E.P. ANDRUSYAKOVA1, A.Yu. SAFONENKO2, E.E. IOYLEVA1
1S. Fyodorov Eye Microsurgery Federal State Institution, 59а Beskudnikovsky Blvd, Moscow, Russian Federation, 127486
2A.I. Evdokimov Moscow State University of Medicine and Dentistry, 20/1 Delegatskaya Str., Moscow, Russian Federation, 127473
Andrusyakova E.P. ― postgraduate student of Ophthalmo-oncology and Radiology Department, e-mail: andr@proandro.ru
Safonenko A.Yu. ― postgraduate student of Eye Diseases Department, e-mail: ia567@mail.ru
Ioyleva E.E. ― D. Sc. (medicine), Professor, Academic Secretary, tel. (499) 488-85-24, e-mail: nauka@mntk.ru
Scientific studies have reliably shown that the quality of life indicators of patients with MS correlate with the structural integrity of the retina architectonics measured by OCT. The thinning of the RNFL layer observed in OCT in patients with MS is associated with a number of clinical manifestations of the disease, depending on the progression of demyelination and neurodegeneration. Progressive loss of the optic nerve axons in patients with MS without optic neuritis has been demonstrated by numerous studies. The authors reported that each year of observation was associated, on average, with a decrease in the thickness of RNFL by 2 μm. Reduction of the level of retinal ganglion cells can be registered earlier than the loss of RNFL. In S. Fyodorov Eye Microsurgery Federal State Institution, a study was performed to evaluate the OCT parameters of the optic nerve disc in patients with MS and it was proved that the ganglion cells lesion begins as early as at the manifestation of the disease, while the RNFL thinning in the eyes of patients with MS is revealed before the visual acuity is reduced.
Key words: multiple sclerosis, optical coherence tomography, optical neuritis, layer of nerve fibers, ganglion cells, magnetic resonance imaging
(For citation: Andrusyakova E.P., Safonenko A.Yu., Issues of neurodegeneration and demyelination in MS according to optical coherence tomography. Practical Medicine. 2018)
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