S.N. IVANOVA^1,2, S.A. GLADKOV^1,2, M.N. BROVKOV¹  

¹Northern State Medical University, Arkhangelsk

²Arkhangelsk Regional Clinical Hospital, Arkhangelsk

Contact:

Ivanova S.N. ― PhD (medicine), Associate Professor of the Department of Hospital Therapy and Endocrinology

Address: 51 Troitsky Pr., Arkhangelsk, Russian Federation, 163000, tel. (8182) 63-29-96, e-mail: [email protected]

The review is devoted to a rare disease ― intravascular large B-cell lymphoma (IVLBCL) ― a form of diffuse large cell lymphomas. Diagnosis of this tumor is very difficult as its cells are located in small vessels, so this lymphoma can be manifested by the clinic of another oncological disease or a lesion of the most involved organ. Practitioners of various specialties may face IVLBCL, suspect paraneoplastic syndrome, but not identify the primary focus of the malignant tumor. It is diagnosed mainly posthumously during histological investigation including immunohistochemical analysis. More than a thousand cases of IVLBCL are described in the world, with only one description in the Russian literature. This review is devoted to the generalization of clinical masks, diagnosis and treatment of IVLBCL.

Key words: intravascular large B-cell lymphoma, immunohistochemical analysis, review.

(For citation: Ivanova S.N., Gladkov S.A., Brovkov M.N. Intravascular large B-cell lymphoma: various clinical masks of paraneoplastic syndrome (literature review). Practical medicine. 2020. Vol. 18, №1, P. 110-115 )

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