Influence of vitamin D on the course and outcomes of pregnancy in women
L.I. MALTSEVA1, E.N. VASILYEVA2,3, T.G. DENISOVA2,3, Yu.V. GARIFULLOVA4
1Kazan State Medical Academy — Branch Campus of the FSBEI FPE RMACPE MOH Russia, Kazan
2Chuvash State University named after I.N. Ulyanov, Cheboksary
3Institute for Doctors’ Advanced Education, Cheboksary
4Kazan State Medical University of the Ministry of Health of the Russian Federation, Kazan
Contact:
Maltseva L.I. — MD, Professor of the department of Obstetrics and Gynecology
Address: 36 Butlerov Str., 420012, Kazan, Russian Federation, tel. +7-905-314-40-51, e-mail: [email protected]
The article presents analysis of literature data on the relation between vitamin D provision and pregnancy course in women. The authors emphasize high frequency of vitamin D deficit in pregnant women living in various latitudes, and its adverse influence on health during pregnancy. Blood serum level of 25OHD<32 ng/ml increases the risk of preeclampsia, gestation diabetes mellitus in mother and pre-mature births, increases the frequency of cesarean section and bacterial vaginosis; leads to low weight of a fetus and a newborn, to inhibition of hip growth in a fetus, impaired cardial function in babies, craniotabes, acute infection of lower respiratory tract, and hypocalcaemia. The recommended doses of vitamin D are analyzed to prevent severe complications of pregnancy. Conclusion is made about the need to correct efficiency or insufficiency of vitamin D in blood serum up to its optimal level of 40 ng/ml, which ensured favorable course of pregnancy.
Key words: vitamin D, 25(OH)D, pregnancy, complications of pregnancy, preeclampsia, gestation diabetes mellitus, fetus growth inhibition.
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