N.M. GRUBER, E.K.VALEEV, A.A. SHULMAN

Republican clinical hospital of the MH of RT, 138 Orenburgskiy Trakt, Kazan, Russian Federation, 420064

Gruber N.M. — Cand. Biol. Sc., Leading Researcher, tel. (843)237-31-84, e-mail: rkb_nauka@rambler.ru

Valeev E.K. — D. Med. Sc., Chief Researcher, tel. (843) 237-31-84, e-mail: rkb_nauka@rambler.ru

Shulman A.A. — Senior Researcher, tel. (843) 237-31-84, e-mail: rkb_nauka@rambler.ru

 65 patients with spine and spinal cord trauma were observed. It was revealed that the emerging metabolic disorders, expressed by deficiency of protein, energy and mineral resources, are associated with the severity and level of damage to the spinal cord, caused by developing degenerative changes in the neuromotor apparatus, lead to distorted regulation of vital functions by initiating decreased bone regeneration.

Key words: vertebral spinal injury, metabolic disorders, bone regeneration.

REFERENCES

1. Afaunov A.A., Kuz’menko A.V. Transpedicular fixation for lesions of thoracic and lumbar spine, accompanied by traumatic stenosis of the spinal canal. Khirurgiya pozvonochnika, 2011, no. 4, pp. 8–17 (in Russ.).
2. Tsiv’yan Ya.L. Povrezhdeniya pozvonochnika [Damage to the spine]. Moscow: Meditsina, 1971. 312 p.
3. Seleznev S.A., Khudayberenov G.S. Travmaticheskaya bolezn’ [Traumatic illness ]. Ashkhabad: YLYM, 1984. 223 p.
4. Babichenko N.E. Narushenie vzaimosvyazi sistem svertyvaniya i fibrinoliza u bol’nykh s razlichnym urovnem travmy spinnogo mozga: tezisy. Mat-ly Vses. konf. “Fiziologiya vegetativnoy nervnoy sistemy” [Infringement of interrelation of systems of coagulation and fibrinolysis at patients with various level of a trauma of a spinal cord: theses. Materials All. Conf. “Physiology of the autonomic nervous system”]. Kuybyshev, 1979. Pp. 25–26.
5. Stogov M.V., Luneva S.N. Biochemical indicators in assessing the severity of traumatic effects. Klin. lab. diagn, 2008, no. 11, pp. 15–17 (in Russ.).

6. Smolichev E.P. Regulyatsiya belkovogo sostava plazmy v usloviyakh patologii: tezisy. Mat-ly konf. Patofiziologov [Regulation of the protein composition of plasma in pathological conditions: theses. Materials conf. pathophysiologists]. Moscow, 2010. P. 157.
7. Tkachuk E.A., Luneva S.N.,  Stogov M.V. Biokhimicheskie osnovy adaptatsii cheloveka k skeletnoy travme. Fiziologicheskie mekh-my adaptatsii cheloveka: mat-ly mezhdunar. nauchno-prakt. konf. [Biochemical basis of human adaptation to skeletal trauma. Physiological mechanisms of human adaptation: materials of the international. scientific and practical work. Conf]. Tyumen, 2010. Pp. 140–141.
8. Tkachuk E.A., Luneva S.N., Stogov M.V. Biochemical parameters of blood serum as markers of complications in closed fractures of the shin bones. Klin. lab. diagn, 2011, no. 10, p. 43 (in Russ.).
9. Thompson R.C., Ludewig R.M., S.L. Wandengennsteen, L.M. Rudolf Effects of heparin on wound healing. Surg. Gynec. Obstet, 1972, vol. 134, p. 22.
10. Flamark A.L. Fracture union in the presence of delayed blood coagulation. Acta. Chir. Scand, 1964, suppl. 344, pp. 1–4.
11. Minchenko B.I. Biochemical indices of metabolic disturbances of bone tissue. Klin. lab. diagn, 1999, no. 1, pp. 8–15 (in Russ.).
12. Labori A. Regulyatsiya obmennykh protsessov [Regulation of metabolic processes]. Moscow, 1970. 383 p.
13. Gatiyatullin N.R., Davkhale R., Fakhrutdinova L.I. Correction of mineral-bone disorders in a patient with chronic kidney disease of the 5th stage by software hemodialysis (wedge observation). Prakt. meditsina, 2016, no. 4 (96), vol. 1, pp. 71–73 (in Russ.).
14. Schmidt U., Porusche G., Jung H. (e. a.) Heparin und Osteoporose. Dtsch. Gesundheitswes, 1973, bd. 28, pp. 630–638.
15. Skal’nyy A.A. Ekologo-fiziologicheskoe obosnovanie effektivnosti makro- i mikroelementov pri narusheniyakh gomeostaza u obsleduemykh iz raznykh klimato-geograficheskikh regionov: avtoref. dis. dokt. med. nauk [Ecological and physiological substantiation of the effectiveness of macro- and microelements in cases of homeostasis disturbances in the subjects from different climatic and geographical regions. Synopsis of dis. Dr sciences]. Moscow, 2000. 43 p.
16. Dolgov V., Morozova V., Martsishevskaya R. et al. Kliniko-diagnosticheskoe znachenie laboratornykh pokazateley [Clinical and diagnostic significance of laboratory indicators ]. Moscow: Tsentr, 1995. 215 p.
17. Shein A.P., Krivoruchko G.A. Influence of spinal cord injury level on the severity and dynamics of electroneuromyographic characteristics of the severity of sensorimotor disorders. Khirurgiya pozvonochnika, 2013, no. 2, pp. 45–51 (in Russ.).