O.V. LAPSHINA¹, E.A. ANTIPENKO², K.N. KONTORSHCHIKOVA², A.V. BARANOVA³, D.V. SEDYSHEV¹, A.V. GUSTOV²

¹Nizhny Novgorod Regional Clinical Hospital named after N.A. Semashko, 190 Rodionov Str., Nizhniy Novgorod, Russian Federation, 603126

²Nizhny Novgorod State Medical Academy, 10/1 Minin and Pozharskiy Square, Nizhny Novgorod, Russian Federation, 603005

³Nizhny Novgorod National Research State University named after N.I. Lobachevsky, 23 Gagarin Pr., Nizhny Novgorod, Russian Federation, 603022 

Lapshina O.V. ― doctor-neurologist of the 1^st Neurological Department, correspondence postgraduate student of the Department of Neurology, Psychiatry and Narcology, tel. +7-908-232-11-31, e-mail: [email protected]

Antipenko E.A. ― D. Med. Sc., Associate Professor of the Department of Neurology, Psychiatry and Narcology, tel. +7-951-919-41-96, e-mail: [email protected]

Kontorshchikova K.N. ― D. Biol. Sc., Professor, Head of the Department of Clinical Laboratory Diagnostics, tel. +7-903-055-71-99, e-mail: [email protected]

Baranova A.V. ― 4^th year student of the Institute of Biology and Biomedicine, tel. +7-960-180-16-73, e-mail: [email protected]

Sedyshev D.V. ― Cand. Med. Sc., Head of the 1^st Neurological Department, tel. +7-910-141-39-51, e-mail: [email protected]

Gustov A.V. ― D. Med. Sc., Professor, Head of the Department of Neurology, Psychiatry and Narcology, tel. +7-910-873-93-57, e-mail: [email protected]

Myasthenia gravis is a serious disease leading to disability of patients and frequent deaths, which determines the high relevance in the search for pathogenetical methods to increase the efficiency of treatment of this pathology. The activation of free radical oxidation, as a typical pathological process, is an important link in the pathogenesis of several autoimmune diseases, including myasthenia gravis. In the study of oxidative homeostasis in 20 patients with myasthenia gravis, there were changes of oxidative homeostasis in patients with myasthenia as compared with healthy volunteers. The dynamics was analyzed of oxidation processes and antioxidant activity indicators in the therapeutic complex of ozone therapy. There was a positive influence of ozone therapy on the processes of free radical oxidation, which makes ozone therapy pathogenetically substantiated method of treatment of myasthenia gravis.

Key words: myasthenia gravis disease, ozone therapy, lipid peroxidation.

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