D.R. AGLIULLIN¹, M.V. POTAPOVA², S.T. AGLUILLINA¹, A.A. KHABIBULLINA^{1, 2}, O.V. SHARIPOVA², I.V. VASILYEVA²

 ¹ Kazan State Medical University, Kazan

² City Children’s Hospital № 1, Kazan

 Contact details:

Agliullin D.R, postgraduate student, Assistant Lecturer of the Department of Epidemiology and Evidence-based Medicine

Address: 49 Butlerov St., Russian Federation, Kazan, 420012, tel.: +7 (843) 236-68-92; e-mail: [email protected]

 The purpose of the study was to evaluate the impact of vaccination against influenza and pneumococcal infection on the frequency of respiratory tract infections among 4–5 y. o. children.

Material and methods. 73 development histories of children (accounting form 112) (at the beginning of 2019) were analyzed. Data on vaccination against influenza (in 2017) and pneumococcal infection (PCI), data on children’s attendance at children’s educational institutions, on the clinical forms and frequency of respiratory tract infections in 2018 were selected. We counted the presence of vaccination against PCI at the end of the vaccination course no later than December 2017.

Results. Children unvaccinated against influenza were statistically significantly more likely to have acute respiratory infections (ARI) than vaccinated children (U = 163, p < 0,001): the median of ARI cases among unvaccinated children in 2018 was 3 (25–75% = 2–4), ranging from 1 to 13 cases per year; among those vaccinated against flu the median was 2 (25–75% = 1–2), varying from 1 to 4 cases of ARI per year. Children unvaccinated against PCI statistically significantly more often had ARI than vaccinated (U = 466, p = 0,03): the median of infection cases among the unvaccinated children in 2018 amounted to 3 (25–75% = 2–5), varying from 1 to 13 cases per year, among vaccinated — 2 (25–75% = 2–4), varying from 1 to 6 cases of ARI per year. According to the regression analysis results, the frequency of ARI cases in children unvaccinated against influenza was 1,42 higher than in vaccinated children (p = 0,008). The presence of a course of vaccination against PCI reduces the frequency of ARI cases during a year by 1,07 (p = 0,013). Kindergarten attendance, on the other hand, increases the ARI incidence in children by 1,43 cases.

Conclusion. The positive effect of vaccination against influenza and pneumococcal infection on the incidence of acute respiratory infections in children during a year was revealed. Children vaccinated against flu and PCI get ARI less often than unvaccinated children.

Key words: influenza, pneumococcal infection, vaccination, recurrent respiratory infections, respiratory tract infection, children.

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