M.Yu. SMETANIN¹, L.T. PIMENOV², T.E. CHERNYSHOVA²

¹Republic Clinical-diagnostic Center, 87b Lenin Str., Izhevsk, Russian Federation, 426009

²Izhevsk State Medical Academy, 281 Kommunarov Str., Izhevsk, Russian Federation, 426034

 Smetanin M.Yu. — Cand. Med. Sc., doctor of the Department of Ultrasound Diagnostics, tel. 7-912-856-03-33, e-mail: [email protected]

Pimenov L.T. — D. Med. Sc., Professor, Head of the Department of General Practice and Internal Diseases with the course of emergency medical assistance, tel. (3412) 66-11-33, e-mail: [email protected]

Chernyshova T.E. — D. Med. Sc., Professor of the Department of General Practice and Internal Diseases with the course of emergency medical assistance, tel. (3412) 66-11-33, e-mail: [email protected]

 The objective of the research is a comparative study of hormones-regulators of bone metabolism and biochemical markers of mineral metabolism (calcium, phosphorus, magnesium) in female patients with differentiated and undifferentiated forms of connective tissue dysplasia (CTD). We evaluated the bone metabolism and the processes of bone tissue remodeling as well. Assessment of blood levels of thyroid-stimulating hormone, triiodothyronine, parathyroid hormone, prolactin, adrenocorticotropic hormone, cortisol, growth hormone and electrolytes (calcium, phosphorus, magnesium), bone resorption (osteocalcin and alkaline phosphatase) and bone formation (deoxypyridinoline, urine calcium) markers was performed in 120 patients (105 with undifferentiated form of CTD and 15 with Marfan syndrome). In patients with Marfan syndrome, the decrease of magnesium content and increase of phosphorus level under normal calcium concentration in blood serum was found. Under hereditary dysplasia of connective tissue, the hormonal profile is characterized by fluctuations in ACTH and parathyroid hormone, mainly in female patients with Marfan syndrome.

Key  words: biochemical markers, bone metabolism, connective tissue dysplasia

REFERENCES

1. Bakulina E.G. Clinical and biochemical diagnostics of mineral metabolism and regulating hormones of metabolism in connective-tissue bone dysplasia. Kubanskiy nauchnyy meditsinskiy vestnik, 2009, no. 6 (111), pp. 10–13 (in Russ.).
2. Loeys B.L. The Revised Ghent Nosology for the Marfan Syndrome. J. Med. Genet., 2010, vol. 4, pp. 476–485.
3. National recommendations of the Russian scientific medical society of therapists for diagnosis, treatment and rehabilitation of patients with connective tissue dysplasia. Meditsinskiy vestnik Severnogo Kavkaza, 2016, vol. 11, no. 1, pp. 1–76 (in Russ.).